Természetes eredetu O- és C-prenilezett flavanonok szintézise és antifungális aktivitásuk vizsgálata

Translated title of the contribution: Synthesis and antifungal activity of naturally occurring O- and C-prenylated flavanones

Ágnes Kenéz, László Juhász, Zsombor Lestár, Béla Lenkey, Sándor Antus

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Flavonoids is one of the most important groups of naturally occurring O-heterocycles possessing a wide range of biological activity. O- and C-prenylated flavanones as members of flavonoids also show remarkable biological activity such as antibacterial, antiviral, anti-tumor, antifungal, anti-HIV and enzyme inhibition activity. O- and C-prenylated flavanones possessing remarkable biological activity are representatives of this family of natural products. In this paper efficient synthetic methods have been reported for the preparation of O-(2, 3) and C-(4, 5) prenylated flavanones isolated from Monotes engleri and their analogues (26-30; 38-43) starting from commercially available starting materials. In vitro pharmacological examinations of our compounds were performed on different Candida species (Candida albicans, Candida inconspicua, Candida dubliniensis, Candida krusei) by agardiffusion method. Our structure-activity relationship study clearly showed that any modification of the structure of selinone (2) and monotesone-A (3) led to the total loss the fungistatic activity.

Translated title of the contributionSynthesis and antifungal activity of naturally occurring O- and C-prenylated flavanones
Original languageHungarian
Pages (from-to)5-10
Number of pages6
JournalActa pharmaceutica Hungarica
Volume77
Issue number1
Publication statusPublished - Apr 27 2007

ASJC Scopus subject areas

  • Pharmaceutical Science

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