Synthesis and anti-arrhythmic activity of aminoguanidine derivatives

I. Érczi, G. Rablóczky, A. Varró, G. Somogy I, M. Kürthy, I. Bódy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A series of new aminoguanidine derivatives were synthesized and tested for anti-arrhythmic activity. The compounds selected were investigated on other test models. Finally, compound 13 1-(2,6-dimethylphenyl)-4,4-dimethyl-aminoguanidine-hydrochloride (B-GYKI-38 233) was chosen for detailed study.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume28
Issue number3
DOIs
Publication statusPublished - 1993

Keywords

  • aminoguanidines
  • anti-arrhythmic activity

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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