Syntheses d'analogues peptidiques et pseudo-peptidiques de la cholecystokinine

Translated title of the contribution: Syntheses of peptide and peptoid analogues of cholecystokinin

Laurent Jeannin, Janos Sapi, Dominique Cartier, Jean Yves Laronze, Bruno Maigret, Botond Penke

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe selective CCKA receptor antagonists, based on the 1-oxo- 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid core. Selectivity A vs B is discussed on the basis of molecular modelling. Chemical preparation uses electrophilic cyclization of isocyanates derivating from unnatural tryptophan esters. A stereoselective version of the reaction is given. A few peptides incorporating unnatural tryptophans are prepared, with a view of SAR.

Original languageFrench
Pages (from-to)135-140
Number of pages6
JournalAnnales Pharmaceutiques Francaises
Volume55
Issue number3
Publication statusPublished - 1997

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Peptoids
Cholecystokinin
Tryptophan
Isocyanates
Peptides
Cyclization
Esters

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Jeannin, L., Sapi, J., Cartier, D., Laronze, J. Y., Maigret, B., & Penke, B. (1997). Syntheses d'analogues peptidiques et pseudo-peptidiques de la cholecystokinine. Annales Pharmaceutiques Francaises, 55(3), 135-140.

Syntheses d'analogues peptidiques et pseudo-peptidiques de la cholecystokinine. / Jeannin, Laurent; Sapi, Janos; Cartier, Dominique; Laronze, Jean Yves; Maigret, Bruno; Penke, Botond.

In: Annales Pharmaceutiques Francaises, Vol. 55, No. 3, 1997, p. 135-140.

Research output: Contribution to journalArticle

Jeannin, L, Sapi, J, Cartier, D, Laronze, JY, Maigret, B & Penke, B 1997, 'Syntheses d'analogues peptidiques et pseudo-peptidiques de la cholecystokinine', Annales Pharmaceutiques Francaises, vol. 55, no. 3, pp. 135-140.
Jeannin, Laurent ; Sapi, Janos ; Cartier, Dominique ; Laronze, Jean Yves ; Maigret, Bruno ; Penke, Botond. / Syntheses d'analogues peptidiques et pseudo-peptidiques de la cholecystokinine. In: Annales Pharmaceutiques Francaises. 1997 ; Vol. 55, No. 3. pp. 135-140.
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