Syntheses and advanced NMR structure determination of androsteno-[17,16-d]-pyrimidine derivatives

P. Forgó, Irén Vincze

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Reactions of 16-hydroxymethylene- and 16-aminomethylene-3β-hydroxy-5-androsten-17-one with formamide and guanidine were carried out resulting in the formation of [16,17-d]-pyrimidine rings. Advanced two-dimensional NMR methods were used to investigate the structure of the products. Homonuclear-, and heteronuclear chemical shift correlation experiments yielded the complete 1H-, 13C- and 15N signal assignment for these compounds.

Original languageEnglish
Pages (from-to)749-756
Number of pages8
JournalSteroids
Volume67
Issue number9
DOIs
Publication statusPublished - 2002

Fingerprint

Guanidine
Chemical shift
Nuclear magnetic resonance
Derivatives
Experiments
formamide
androsteno-(17,16-d)-pyrimidine
pyrimidine

Keywords

  • Androstene
  • NMR spectroscopy
  • Pyrimidino-androstenes
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Syntheses and advanced NMR structure determination of androsteno-[17,16-d]-pyrimidine derivatives. / Forgó, P.; Vincze, Irén.

In: Steroids, Vol. 67, No. 9, 2002, p. 749-756.

Research output: Contribution to journalArticle

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