Synthese of 13-oxa- and 13-thia-PGI2: metabolically stable and biologically potent PGI2 analogues

Lajos Novák, József Aszódi, Csaba Szántay

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12 Citations (Scopus)

Abstract

13-Oxa-13,14-dihydro-PGI2 (6) and 13-thia-13,14-dihydro-PGI2 (9) were synthesized from the corresponding PGF analogues via iodo ether formation and subsequent elimination of HI.

Original languageEnglish
Pages (from-to)2135-2138
Number of pages4
JournalTetrahedron Letters
Volume23
Issue number20
DOIs
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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