Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis

J. Molnár, I. Haszon, T. Bodrogi, E. Martonyi, S. Turi

Research output: Contribution to journalArticle

33 Citations (Scopus)


The effects of promethazine were studied in children with frequently recurring pyelonephritis which was not associated with urological abnormalities. The results of three methods of treatment were compared: 10 children were given a combination of gentamycin and promethazine for 7 days (Group 1), 11 received gentamycin treatment alone for 10 days (Group 2), and 19 (Group 3) were on long-term oral antibiotic prophylaxis (5.6±2.1 years) with episodes of intensive treatment of recurrences. In a 3-year follow-up period, the number of pyelonephritis recurrences was significantly lower in Group 1 than in Groups 2 and 3. Six out of 19 children in Group 3 had renal scarring. The authors suggest a synergistic effect between gentamycin and promethazine therapy. Promethazine increases antibiotic sensitivity, which could contribute to the elimination of recurring urinary tract infections.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalInternational urology and nephrology
Issue number5
Publication statusPublished - Sep 1 1990

ASJC Scopus subject areas

  • Nephrology
  • Urology

Fingerprint Dive into the research topics of 'Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis'. Together they form a unique fingerprint.

  • Cite this