Synergistic antibiotic combinations for colistin-resistant Klebsiella pneumoniae

Béla Kádár, Béla Kocsis, Ákos Tóth, Ivelina Damjanova, Máté Szász, Katalin Kristóf, Károly Nagy, Dóra Szabó

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7 Citations (Scopus)

Abstract

In this study antibiotic combinations for multidrug-resistant Klebsiella pneumoniae strains were investigated. The study included a colistin-susceptible and a colistin-resistant KPC-2 producing K. pneumoniae ST258 strains isolated in 2008 and 2009 during an outbreak in Hungary. Antibiotic combinations were analyzed by checkerboard technique and fractional inhibitory concentration indices were calculated. The following antibiotics were tested: ceftazidime, cefotaxime, ceftriaxone, ampicillin, imipenem, ertapenem, amikacin, tobramycin, ciprofloxacin, levofloxacin, moxifloxacin, rifampicin, polymyxin B and colistin. Combinations including 0.25 μg/ml colistin plus 1 μg/ml rifampicin, 0.25 μg/ml polymyxin B plus 1 μg/ml rifampicin, 1 μg/ml imipenem plus 2 μg/ml tobramycin, were found synergistic.These in vitro synergistic combinations suggest potential therapeutical options against infections caused by KPC-2 producing, multidrug-resistant K. pneumoniae ST258.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalActa microbiologica et immunologica Hungarica
Volume60
Issue number2
DOIs
Publication statusPublished - Jun 1 2013

Keywords

  • Klebsiella pneumoniae
  • colistin
  • multidrug-resistance
  • synergism

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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