Syndecans and the lymphoid system

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Syndecans, transmembrane proteoglycans, play an important role in cell-matrix and cell-cell interactions, as well as modulators in receptor activation. These functions are partly non-specific and related to the heparan sulfate chains attached to the ectodomain, and partly specific due to the transmembrane and cytoplasmic domains of the core protein. In hemopoietic cells syndecan-1 is expressed only in B cells at certain differentiation stages (pre-B and plasma cells). In lymphoproliferative conditions this selective expression is retained in myelomas/plasmacytomas and other lymphoplasmacytic NHL subtypes, and primary effusional lymphomas. It is probably gained in B-CLL, and lost in other NHLs of pre- or post-follicular origin. It is concluded from these empiric results that the expression of syndecan is essential for some NHLs, probably ensuring the required connections to the microenvironment. From a diagnostic point of view, syndecan-1 is a very useful phenotypic marker to indentify cells with plasmacytic differentiation. The importance of syndecan expression in CLL and Hodgkin's lymphoma still requires further studies.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalLeukemia and Lymphoma
Volume38
Issue number3-4
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Heparan sulfate
  • Lymphoma
  • Syndecan

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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