Syndecan-1 in Liver Diseases

Eszter Regős, Katalin Karászi, Andrea Reszegi, András Kiss, Z. Schaff, Kornélia Baghy, I. Kovalszky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver. Despite the emerging data of the biological function of syndecan-1, the clinical usefulness of this proteoglycan is still unknown. In our study we correlated syndecan-1 expression to clinico-pathological data. We found that syndecan-1 proved to be a good marker for hepatitis C virus based hepatocellular carcinoma and increased with liver dysfunction.

Original languageEnglish
JournalPathology and Oncology Research
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Syndecan-1
Liver Diseases
Proteoglycans
Liver
Liver Neoplasms
Hepacivirus
Liver Cirrhosis
Hepatocytes
Hepatocellular Carcinoma

Keywords

  • Cirrhosis
  • Hepatocellular carcinoma
  • Liver
  • Metastasis
  • Syndecan-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Syndecan-1 in Liver Diseases. / Regős, Eszter; Karászi, Katalin; Reszegi, Andrea; Kiss, András; Schaff, Z.; Baghy, Kornélia; Kovalszky, I.

In: Pathology and Oncology Research, 01.01.2019.

Research output: Contribution to journalArticle

Regős, Eszter ; Karászi, Katalin ; Reszegi, Andrea ; Kiss, András ; Schaff, Z. ; Baghy, Kornélia ; Kovalszky, I. / Syndecan-1 in Liver Diseases. In: Pathology and Oncology Research. 2019.
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