Purpose of study: Syndecan-1 (epithelial syndecan; a transmembrane proteoglycan) is expressed in normal squamous cells, transitional cells and plasma cells. Temporarily it appears in condensating mesenchyma during embryonal development, and in the endothelial cells of the granulation tissue in wound healing. It is present in malignant epithelial cells (depending on the grade) and hematological neoplasias. The question was how syndecan-1 is expressed in benign and malignant vascular tumors as well as in soft tissue tumors of epithelioid character. Methods: Expression of syndecan-1 was studied in 10 pyogenic granulomas and 10 Kaposi's sarcomas, and in 5 epithelioid sarcomas using monoclonal anti-syndecan-1 antibody, besides otherphenotypic markers. Results: Neither pygenic granulomas nor Kaposi's sarcomas reacted with anti-syndecan-1 antibody. However, in epithelioid sarcomas more than 90% of tumor cells showed intensive membrane positivity. Discussion: Although more and more data are available on the structure and function of syndecan-1, less is known about its appearance and rote in human malignancies, especially soft tissue sarcomas. Our results indicate that the proliferation of endothelial cells in vascular tumors or in the stroma was not accompanied by syndecan-1 expression. But it was present on the epithelioid sarcoma cells suggesting its relationship with the epithelioid phenotype.
|Translated title of the contribution||Syndecan-1 expression in vascular tumors and epithelioid sarcomas|
|Number of pages||4|
|Publication status||Published - Dec 1 1999|
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