Syndecan-1 expression in different soft tissue tumours

Z. Orosz, L. Kópper

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: In vitro studies have suggested that expression of syndecan-1 (CD138) is correlated with morphologic phenotype (epithelioid or spindle) of cultured tumour cells. Materials and Methods: Fifty-seven different soft tissue tumours were selected to analyse their syndecan-1 (CD138) reactivity. Immunohistochemical staining of paraffin sections, following a high temperature unmasking technique, was performed. The intensity and the pattern of staining was studied. Results: Cell membrane positivity was observed in epithelioid sarcomas and epithelial elements of synovial sarcomas. GISTs, some malignant epithelioid schwannoma and some fibromatosis showed intracytoplasmatic reaction, while pyogenic granuloma, Kaposi's sarcoma, fibrosarcoma and dermatofibrosarcoma protuberans were negative. Conclusion: At first it seemed that the cell membrane positivity of syndecan-1 accompanied true epithelial differentiation in soft tissue sarcomas, but the results further highlighted the non specific nature of this expression. Therefore the heterogeneity in the appearance of syndecan-1 in various soft tissue tumours is not simply associated with the phenotype, suggesting more complex functions.

Original languageEnglish
Pages (from-to)733-737
Number of pages5
JournalAnticancer Research
Volume21
Issue number1 B
Publication statusPublished - 2001

Fingerprint

Syndecan-1
Sarcoma
Neoplasms
Cell Membrane
Pyogenic Granuloma
Dermatofibrosarcoma
Staining and Labeling
Cultured Tumor Cells
Phenotype
Synovial Sarcoma
Fibroma
Fibrosarcoma
Kaposi's Sarcoma
Neurilemmoma
Paraffin
Temperature

Keywords

  • Extraabdominal
  • Fibromatosis
  • Gastrointestinal stromal tumour
  • Pyogenic granuloma
  • Soft tissue sarcomas
  • Syndecan-1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Syndecan-1 expression in different soft tissue tumours. / Orosz, Z.; Kópper, L.

In: Anticancer Research, Vol. 21, No. 1 B, 2001, p. 733-737.

Research output: Contribution to journalArticle

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