Synaptonemal complex analysis of a three-breakpoint translocation in a subfertile bull

A. Kovács, D. A.F. Villagómez, Gustavsson Gustavsson, K. Lindblad, R. H. Foote, T. H. Howard

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Abstract

Somatic chromosome analysis of a subfertile Brown Swiss bull demonstrated a three-breakpoint translocation involving chromosomes 1, 8, and 9 in G- and R-banded karyotypes. Based on standard bovine chromosome nomenclature. the translocation was defined as t(1;8;9)(q43;q13;q26). Synaptonemal complex analysis of the chromosome aberration by electron microscopy revealed a hexavalent configuration in 52 of 53 pachytene cells. Twenty-seven cells (51%) had a completely paired hexavalent configuration showing distinctly non-homologous pairings between normal and/or translocated chromosomes involved in the exchanges. Thirteen cells showed a hexavalent configuration with centrally unpaired chromosome segments but with completely paired terminal arms. In 13 cells (including one at zygotene) the translocation chromosomes formed an open hexavalent, and in one cell there were two completely paired trivalents. Thirty-two cells at diakinesis-MI demonstrated 28 configurations, including one large hexavalent. Testicular histology, testis size, and seminal characteristics were normal.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalCytogenetic and Genome Research
Volume61
Issue number3
DOIs
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Kovács, A., Villagómez, D. A. F., Gustavsson, G., Lindblad, K., Foote, R. H., & Howard, T. H. (1992). Synaptonemal complex analysis of a three-breakpoint translocation in a subfertile bull. Cytogenetic and Genome Research, 61(3), 195-201. https://doi.org/10.1159/000133407