Synaptic reorganisation of the mediodorsal thalamic nucleus in adult rat following chronic prefrontal cortical lesions

L. Negyessy, J. Takacs, J. Mogensen, I. Divac, J. Hamori

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Chronic changes in the thalamic mediodorsal nucleus (MD) after unilateral lesions of the prefrontal cortex were studied with the aid of quantitative light, and electron microscopic immunohistochemistry. Three months after the lesions, although the size of MD ipsilateral to the lesion did not change considerably, the neuronal density was significantly reduced. Conversely, as demonstrated by quantitative electron microscopy, the density of GABA immunostained axon terminals significantly increased in the lesioned side. It is suggested, that as MD does not contain GABA cells, the reactive hyperinnervation of the MD by GABA-containing axons is of extrinsic origin. This finding is also the morphological evidence of the potential of GABA- ergic nerve cells for reactive (induced) axonal sprouting.

Original languageEnglish
Pages (from-to)433-441
Number of pages9
JournalJournal of Brain Research
Issue number3
Publication statusPublished - Jan 1 1995



  • GABA- immunoreactivity
  • axonal sprouting
  • electron microscopy
  • neuronal degeneration
  • quantitative morphology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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