Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

Erika Bereczki, Paul T. Francis, David Howlett, Joana B. Pereira, Kina Höglund, Anna Bogstedt, Angel Cedazo-Minguez, Jean Ha Baek, Tibor Hortobágyi, Johannes Attems, Clive Ballard, Dag Aarsland

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Introduction Our objective was to compare the levels of three synaptic proteins involved in different steps of the synaptic transmission: Rab3A, SNAP25, and neurogranin, in three common forms of dementia: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia. Methods A total of 129 postmortem human brain samples were analyzed in brain regional specific manner exploring their associations with morphologic changes and cognitive decline. Results We have observed robust changes reflecting synaptic dysfunction in all studied dementia groups. There were significant associations between the rate of cognitive decline and decreased levels of Rab3 in DLB in the inferior parietal lobe and SNAP25 in AD in the prefrontal cortex. Of particular note, synaptic proteins significantly discriminated between dementia cases and controls with over 90% sensitivity and specificity. Discussion Our findings suggest that the proposition that synaptic markers can predict cognitive decline in AD, should be extended to Lewy body diseases.

Original languageEnglish
Pages (from-to)1149-1158
Number of pages10
JournalAlzheimer's and Dementia
Volume12
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • Alzheimer's disease
  • Cognitive impairment
  • Dementia with Lewy bodies
  • Neurogranin
  • Parkinson's disease with dementia
  • Rab3A
  • SNAP25
  • Synaptic dysfunction

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Bereczki, E., Francis, P. T., Howlett, D., Pereira, J. B., Höglund, K., Bogstedt, A., Cedazo-Minguez, A., Baek, J. H., Hortobágyi, T., Attems, J., Ballard, C., & Aarsland, D. (2016). Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia. Alzheimer's and Dementia, 12(11), 1149-1158. https://doi.org/10.1016/j.jalz.2016.04.005