Synaptic input to the axon hillock and initial segment of inhibitory interneurons in the cerebellar cortex of the rat - An electron microscopic study

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The axon hillock (AH) and initial segment (IS) of 10 Golgi neurons and 6 basket cells in the cerebellar cortex of the rat were investigated by electron microscopy using serial sections. An average of 10.4 and 11.3 synaptic terminals were observed to establish synaptic contact with the axon hillock region of Golgi and basket cells, respectively. Most of these terminals were identified as the varicosities of the ascending parallel fibers. It is suggested that the focal innervation of AH regions represents an excitatory input pattern which is basically different from the randomly distributed, huge, parallel-fiber input onto the dendritic trees of Golgi and basket cells. In contrast to Golgi and basket neurons, no accumulation of parallel-fiber synapses was observed around the AH of stellate cells. The IS proper of the three neuronal types were devoid of true axo-axonal synapses.

Original languageEnglish
Pages (from-to)553-562
Number of pages10
JournalCell and Tissue Research
Volume217
Issue number3
DOIs
Publication statusPublished - Jun 1981

Fingerprint

Cerebellar Cortex
Interneurons
Rats
Electrons
Neurons
Fibers
Synapses
Electron microscopy
Presynaptic Terminals
Electron Microscopy
Axon Initial Segment
Axons

Keywords

  • Axon hillock
  • Cerebellar cortex
  • Interneurons
  • Rat

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology

Cite this

@article{50f23c485da343138ea7791d43ed46a7,
title = "Synaptic input to the axon hillock and initial segment of inhibitory interneurons in the cerebellar cortex of the rat - An electron microscopic study",
abstract = "The axon hillock (AH) and initial segment (IS) of 10 Golgi neurons and 6 basket cells in the cerebellar cortex of the rat were investigated by electron microscopy using serial sections. An average of 10.4 and 11.3 synaptic terminals were observed to establish synaptic contact with the axon hillock region of Golgi and basket cells, respectively. Most of these terminals were identified as the varicosities of the ascending parallel fibers. It is suggested that the focal innervation of AH regions represents an excitatory input pattern which is basically different from the randomly distributed, huge, parallel-fiber input onto the dendritic trees of Golgi and basket cells. In contrast to Golgi and basket neurons, no accumulation of parallel-fiber synapses was observed around the AH of stellate cells. The IS proper of the three neuronal types were devoid of true axo-axonal synapses.",
keywords = "Axon hillock, Cerebellar cortex, Interneurons, Rat",
author = "J. H{\'a}mori",
year = "1981",
month = "6",
doi = "10.1007/BF00219363",
language = "English",
volume = "217",
pages = "553--562",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Synaptic input to the axon hillock and initial segment of inhibitory interneurons in the cerebellar cortex of the rat - An electron microscopic study

AU - Hámori, J.

PY - 1981/6

Y1 - 1981/6

N2 - The axon hillock (AH) and initial segment (IS) of 10 Golgi neurons and 6 basket cells in the cerebellar cortex of the rat were investigated by electron microscopy using serial sections. An average of 10.4 and 11.3 synaptic terminals were observed to establish synaptic contact with the axon hillock region of Golgi and basket cells, respectively. Most of these terminals were identified as the varicosities of the ascending parallel fibers. It is suggested that the focal innervation of AH regions represents an excitatory input pattern which is basically different from the randomly distributed, huge, parallel-fiber input onto the dendritic trees of Golgi and basket cells. In contrast to Golgi and basket neurons, no accumulation of parallel-fiber synapses was observed around the AH of stellate cells. The IS proper of the three neuronal types were devoid of true axo-axonal synapses.

AB - The axon hillock (AH) and initial segment (IS) of 10 Golgi neurons and 6 basket cells in the cerebellar cortex of the rat were investigated by electron microscopy using serial sections. An average of 10.4 and 11.3 synaptic terminals were observed to establish synaptic contact with the axon hillock region of Golgi and basket cells, respectively. Most of these terminals were identified as the varicosities of the ascending parallel fibers. It is suggested that the focal innervation of AH regions represents an excitatory input pattern which is basically different from the randomly distributed, huge, parallel-fiber input onto the dendritic trees of Golgi and basket cells. In contrast to Golgi and basket neurons, no accumulation of parallel-fiber synapses was observed around the AH of stellate cells. The IS proper of the three neuronal types were devoid of true axo-axonal synapses.

KW - Axon hillock

KW - Cerebellar cortex

KW - Interneurons

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=0019862471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019862471&partnerID=8YFLogxK

U2 - 10.1007/BF00219363

DO - 10.1007/BF00219363

M3 - Article

C2 - 7249050

AN - SCOPUS:0019862471

VL - 217

SP - 553

EP - 562

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 3

ER -