Synaptic connections between substance P-containing axons and estrogen receptor-synthesizing neurons in the medial preoptic area of the rat brain

Imre Kalló, Csaba Fekete, Clive W. Coen, Zsolt Liposits

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dual-label immunocytochemical procedures were employed to provide ultrastructural evidence for the presence of substance P (SP) in afferents to estrogen-receptive neurons in the medial preoptic area (MPO) of the female rat. SP-immunoreactive axon terminals were observed to innervate the periventricular (PvPO) and medial (MPN) preoptic nuclei of the MPO densely, and to form synaptic connections at these sites with neurons which contain estrogen receptors in their nucleus. These results indicate that estrogen-receptive preoptic neurons may be regulated by SP-containing neuronal pathways via synaptic mechanisms.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalBrain research
Volume781
Issue number1-2
DOIs
Publication statusPublished - Jan 19 1998

Keywords

  • Electron microscopy
  • Estrogen receptor
  • Immunocytochemistry
  • Medial preoptic nucleus
  • Periventricular preoptic nucleus
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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