Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics

A. Kardos, D. J. Taylor, C. Thompson, P. Styles, L. Hands, J. Collin, B. Casadei

Research output: Contribution to journalArticle

Abstract

Background. Sympathetic activation may limit exercise performance by restraining muscle blood flow or by negatively affecting skeletal muscle metabolic behavior. To test this hypothesis we studied the effect of thoracoscopic sympathetic trunkotomy (TST) on forearm exercise duration, blood flow, and muscle bioenergetics in 13 patients with idiopathic palmar hyperhidrosis. Methods and Results. Heart rate and beat-by-beat mean arterial pressure (MAP) were recorded at rest and during right and left rhythmic handgrip before and 4-7 weeks after right TST. Forearm blood flow (FBF) was measured bilaterally at rest and on the right during exercise. Right forearm muscle phosphocreatine content and intracellular pH were assessed by 31P magnetic resonance spectroscopy. After right TST, exercise duration increased from 8.9±1.4 to 13.4±1.8 minutes (P

Original languageEnglish
JournalHeart
Volume83
Issue numberSUPPL. 1
Publication statusPublished - May 2000

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Sympathectomy
Forearm
Upper Extremity
Energy Metabolism
Skeletal Muscle
Exercise
Muscles
Hyperhidrosis
Phosphocreatine
Arterial Pressure
Magnetic Resonance Spectroscopy
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kardos, A., Taylor, D. J., Thompson, C., Styles, P., Hands, L., Collin, J., & Casadei, B. (2000). Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. Heart, 83(SUPPL. 1).

Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. / Kardos, A.; Taylor, D. J.; Thompson, C.; Styles, P.; Hands, L.; Collin, J.; Casadei, B.

In: Heart, Vol. 83, No. SUPPL. 1, 05.2000.

Research output: Contribution to journalArticle

Kardos, A, Taylor, DJ, Thompson, C, Styles, P, Hands, L, Collin, J & Casadei, B 2000, 'Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics', Heart, vol. 83, no. SUPPL. 1.
Kardos A, Taylor DJ, Thompson C, Styles P, Hands L, Collin J et al. Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. Heart. 2000 May;83(SUPPL. 1).
Kardos, A. ; Taylor, D. J. ; Thompson, C. ; Styles, P. ; Hands, L. ; Collin, J. ; Casadei, B. / Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. In: Heart. 2000 ; Vol. 83, No. SUPPL. 1.
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