Swinhoeisterols from the South China Sea Sponge Theonella swinhoei

Jiao Li, Hua Tang, T. Kurtán, Attila Mándi, Chun Lin Zhuang, Li Su, Gui Liang Zheng, Wen Zhang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Swinhoeisterols C-F (1-4), four new steroids having a rearranged 6/6/5/7 ring system, were isolated from the Xisha sponge Theonella swinhoei, together with the known analogue swinhoeisterol A (5). Their structures were determined based on spectroscopic analysis, TDDFT-ECD and optical rotation calculations, and biogenetic correlations. In an in vitro assay, compound 1 showed an inhibitory effect on (h)p300 with an IC50 value of 8.8 μM, whereas compounds 2-4 were not active.

Original languageEnglish
Pages (from-to)1645-1650
Number of pages6
JournalJournal of Natural Products
Volume81
Issue number7
DOIs
Publication statusPublished - Jul 27 2018

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Li, J., Tang, H., Kurtán, T., Mándi, A., Zhuang, C. L., Su, L., Zheng, G. L., & Zhang, W. (2018). Swinhoeisterols from the South China Sea Sponge Theonella swinhoei. Journal of Natural Products, 81(7), 1645-1650. https://doi.org/10.1021/acs.jnatprod.8b00281