Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones

Annamária Molnár, Anita Kapros, L. Párkányí, Zoltán Mucsi, Gábor Vlád, I. Hermecz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-one with (het)arylboronic acids allow easy access to (het)aryl and vinyl derivatives of this bicycle in good to excellent yields, even from chloro derivatives. The sequence of reactivity of the halogen in the different positions of the ring system was also investigated. 6-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one could be prepared by thermal cyclization of isopropylidene (6-phenylpyrid-2-ylamino)methylenemalonate, together with a small amount of 7-phenyl-1,4-dihydro-1,8-naphthyridin-4-one.

Original languageEnglish
Pages (from-to)6559-6565
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number19
DOIs
Publication statusPublished - Oct 7 2011

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bicycle
Halogens
cross coupling
Cross Reactions
Palladium
Cyclization
halogens
palladium
halos
reactivity
Hot Temperature
Derivatives
acids
Acids
rings
Bicycles
propylene

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones. / Molnár, Annamária; Kapros, Anita; Párkányí, L.; Mucsi, Zoltán; Vlád, Gábor; Hermecz, I.

In: Organic and Biomolecular Chemistry, Vol. 9, No. 19, 07.10.2011, p. 6559-6565.

Research output: Contribution to journalArticle

Molnár, Annamária ; Kapros, Anita ; Párkányí, L. ; Mucsi, Zoltán ; Vlád, Gábor ; Hermecz, I. / Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones. In: Organic and Biomolecular Chemistry. 2011 ; Vol. 9, No. 19. pp. 6559-6565.
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