Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel

A. Spät, I. Balla, T. Balla, P. Enyedi, G. Hajnoczky, T. Rohacs

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Angiotensin-induced aldosterone production by superfused adrenal glomerulosa cells was potentiated by Ni2+ (0.1 mM), added either at the onset of stimulation with angiotensin II or 1 h later. Nickel did not influence the effect of adrenocorticotropic hormone or potassium on aldosterone production. Nickel failed to modify angiotensin-induced changes in phospholipid metabolism or the formation of inositol phosphates and slightly reduced the enhancement of 45Ca influx. Uptake of Ni2+ into glomerulosa cells was increased by depolarization in a dihydropyridine-insensitive manner. Because nickel selectively potentiates the sustained phase of the response to a calcium-mobilizing hormone, it may serve as a suitable tool in elucidating the signal transduction process during the sustained phase of stimulation.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume258
Issue number4 21-4
Publication statusPublished - 1990

Fingerprint

Nickel
Aldosterone
Angiotensin II
Angiotensins
Zona Glomerulosa
Signal transduction
Inositol Phosphates
Depolarization
Metabolism
Adrenocorticotropic Hormone
Signal Transduction
Phospholipids
Potassium
Hormones
Calcium

Keywords

  • adrenocorticotropic hormone
  • calcium-mobilizing hormones
  • cobalt
  • dihydropyridines
  • glomerulosa cell
  • inositol trisphosphate
  • nickel uptake
  • potassium

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel. / Spät, A.; Balla, I.; Balla, T.; Enyedi, P.; Hajnoczky, G.; Rohacs, T.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 258, No. 4 21-4, 1990.

Research output: Contribution to journalArticle

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AU - Balla, I.

AU - Balla, T.

AU - Enyedi, P.

AU - Hajnoczky, G.

AU - Rohacs, T.

PY - 1990

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N2 - Angiotensin-induced aldosterone production by superfused adrenal glomerulosa cells was potentiated by Ni2+ (0.1 mM), added either at the onset of stimulation with angiotensin II or 1 h later. Nickel did not influence the effect of adrenocorticotropic hormone or potassium on aldosterone production. Nickel failed to modify angiotensin-induced changes in phospholipid metabolism or the formation of inositol phosphates and slightly reduced the enhancement of 45Ca influx. Uptake of Ni2+ into glomerulosa cells was increased by depolarization in a dihydropyridine-insensitive manner. Because nickel selectively potentiates the sustained phase of the response to a calcium-mobilizing hormone, it may serve as a suitable tool in elucidating the signal transduction process during the sustained phase of stimulation.

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