Susceptibility of clinically important dermatophytes against statins and different statin-antifungal combinations

Ildikó Nyilasi, S. Kocsubé, Krisztina Krizsán, László Galgóczy, T. Papp, M. Pesti, K. Nagy, C. Vágvölgyi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The investigation of the antifungal activities of drugs whose primary activities are not related to their antimicrobial potential is in the current forefront of research. Statin compounds, which are routinely used as cholesterol-lowering drugs,may also exert direct antimicrobial effects. In this study, the in vitro antifungal activities of various statins (lovastatin, simvastatin, fluvastatin, atorvastatin, rosuvastatin and pravastatin) were examined against one isolate each of four dermatophyte species (Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis and Microsporum gypseum). Basically, statins were effective in inhibiting all dermatophyte studied, but were particularly active against M. canis and T. mentagrophytes. Fluvastatin and simvastatin were active against all of the tested fungi causing a complete inhibition of their growth at very low concentrations (6.25-12.5 μg/ml). Lovastatin and rosuvastatin had inhibitory effects at higher concentrations (25-128 μg/ml), while atorvastatin and pravastatin proved the less effective. The in vitro interactions between statins and different antifungals (ketoconazole, itraconazole, fluconazole, amphotericin B, nystatin, griseofulvin, terbinafine and primycin) were also investigated using a standard chequerboard broth microdilution method. Synergetic interactions were observed in several cases, most of them were noticed when statins were combined with terbinafine and the different azoles. Some combinations were particularly active (ketoconazole-simvastatin or terbinafine-simvastatin), as they were found to exert synergistic effect against all of the investigated isolates. The other antifungals showed synergistic interactions with statins in only certain cases. These results suggest that statins exert substantial antifungal effects against dermatophyte fungi and they should be promising components in a combination therapy as they can act synergistically with a number of clinically used antifungal agents.

Original languageEnglish
Pages (from-to)140-148
Number of pages9
JournalJournal of Music Therapy
Volume52
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Arthrodermataceae
terbinafine
Simvastatin
fluvastatin
Microsporum
Pravastatin
Lovastatin
Trichophyton
Ketoconazole
Fungi
Griseofulvin
Nystatin
Azoles
Itraconazole
Fluconazole
Antifungal Agents
Amphotericin B
Susceptibility
Pharmaceutical Preparations

Keywords

  • Antifungal susceptibility testing
  • Dermatophytes
  • Drug combination
  • Statin
  • Synergism

ASJC Scopus subject areas

  • Complementary and Manual Therapy
  • Music

Cite this

Susceptibility of clinically important dermatophytes against statins and different statin-antifungal combinations. / Nyilasi, Ildikó; Kocsubé, S.; Krizsán, Krisztina; Galgóczy, László; Papp, T.; Pesti, M.; Nagy, K.; Vágvölgyi, C.

In: Journal of Music Therapy, Vol. 52, No. 2, 2015, p. 140-148.

Research output: Contribution to journalArticle

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