Survival and early complications of preterm infants with birthweight less than 500 grams during a 10-year period in Hungary

Péter Varga, Botond Berecz, Zsófia Magyar, Barbara Pete, Éva Romicsné Görbe, Zsófia Anna Dombi, Lilla Sassi, Eszter Fanczal, Nándor Ács, László Kornya, József Gábor Joó, Andrea Valek, Ágnes Harmath, Ákos Gasparics

Research output: Contribution to journalArticle

Abstract

Background: There are limited data available on the survival and early complications of preterm infants with less than 500 g birthweight. To estimate the outcomes for these infants, it is important for caregivers to be aware of perinatal factors that may affect survival. Objectives: We assessed the mortality and certain early complications of preterm infants born with less than 500 g in Hungary between 2006 and 2015. Methods: We reviewed data of 486 infants from the database of the Hungarian Central Statistical Office and in parallel of 407 infants from the “NICU database.” The study period was divided into two epochs: 2006-2010 and 2011-2015. Results: The survival was 27.1% in the first epoch and 39.1% in the second epoch, and the incidence of early complications was slightly higher in the second epoch. In the surviving group (first and second epoch combined), gestational age (25.1 vs 23.7 weeks), birthweight (458 vs 447 g) antenatal steroid treatment (66.3% vs 52.3%), surfactant therapy (95.1% vs 84.3%), median Apgar scores (6 vs 3 and 8 vs 5 at 1 and 5 minutes, respectively) and proportion of caesarean delivery (89.3% versus 68.5%) were higher than in the non-surviving group (first and second epoch combined). The proportion of multiple births was lower in the surviving group (15.7% vs 33.4%). Conclusions: Survival of infants with less than 500 g improved between 2006-2010 and 2011-2015 in Hungary. The slightly higher occurrence of early complications might be associated with improving survival.

Original languageEnglish
JournalPaediatric and Perinatal Epidemiology
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Hungary
Premature Infants
Survival
Databases
Multiple Birth Offspring
Apgar Score
Surface-Active Agents
Caregivers
Gestational Age
Steroids
Mortality
Incidence
Therapeutics

Keywords

  • early complications
  • extremely low birthweight
  • outcome
  • preterm infants
  • survival

ASJC Scopus subject areas

  • Epidemiology
  • Pediatrics, Perinatology, and Child Health

Cite this

Survival and early complications of preterm infants with birthweight less than 500 grams during a 10-year period in Hungary. / Varga, Péter; Berecz, Botond; Magyar, Zsófia; Pete, Barbara; Romicsné Görbe, Éva; Dombi, Zsófia Anna; Sassi, Lilla; Fanczal, Eszter; Ács, Nándor; Kornya, László; Joó, József Gábor; Valek, Andrea; Harmath, Ágnes; Gasparics, Ákos.

In: Paediatric and Perinatal Epidemiology, 01.01.2019.

Research output: Contribution to journalArticle

Varga, P, Berecz, B, Magyar, Z, Pete, B, Romicsné Görbe, É, Dombi, ZA, Sassi, L, Fanczal, E, Ács, N, Kornya, L, Joó, JG, Valek, A, Harmath, Á & Gasparics, Á 2019, 'Survival and early complications of preterm infants with birthweight less than 500 grams during a 10-year period in Hungary', Paediatric and Perinatal Epidemiology. https://doi.org/10.1111/ppe.12598
Varga, Péter ; Berecz, Botond ; Magyar, Zsófia ; Pete, Barbara ; Romicsné Görbe, Éva ; Dombi, Zsófia Anna ; Sassi, Lilla ; Fanczal, Eszter ; Ács, Nándor ; Kornya, László ; Joó, József Gábor ; Valek, Andrea ; Harmath, Ágnes ; Gasparics, Ákos. / Survival and early complications of preterm infants with birthweight less than 500 grams during a 10-year period in Hungary. In: Paediatric and Perinatal Epidemiology. 2019.
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abstract = "Background: There are limited data available on the survival and early complications of preterm infants with less than 500 g birthweight. To estimate the outcomes for these infants, it is important for caregivers to be aware of perinatal factors that may affect survival. Objectives: We assessed the mortality and certain early complications of preterm infants born with less than 500 g in Hungary between 2006 and 2015. Methods: We reviewed data of 486 infants from the database of the Hungarian Central Statistical Office and in parallel of 407 infants from the “NICU database.” The study period was divided into two epochs: 2006-2010 and 2011-2015. Results: The survival was 27.1{\%} in the first epoch and 39.1{\%} in the second epoch, and the incidence of early complications was slightly higher in the second epoch. In the surviving group (first and second epoch combined), gestational age (25.1 vs 23.7 weeks), birthweight (458 vs 447 g) antenatal steroid treatment (66.3{\%} vs 52.3{\%}), surfactant therapy (95.1{\%} vs 84.3{\%}), median Apgar scores (6 vs 3 and 8 vs 5 at 1 and 5 minutes, respectively) and proportion of caesarean delivery (89.3{\%} versus 68.5{\%}) were higher than in the non-surviving group (first and second epoch combined). The proportion of multiple births was lower in the surviving group (15.7{\%} vs 33.4{\%}). Conclusions: Survival of infants with less than 500 g improved between 2006-2010 and 2011-2015 in Hungary. The slightly higher occurrence of early complications might be associated with improving survival.",
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AU - Varga, Péter

AU - Berecz, Botond

AU - Magyar, Zsófia

AU - Pete, Barbara

AU - Romicsné Görbe, Éva

AU - Dombi, Zsófia Anna

AU - Sassi, Lilla

AU - Fanczal, Eszter

AU - Ács, Nándor

AU - Kornya, László

AU - Joó, József Gábor

AU - Valek, Andrea

AU - Harmath, Ágnes

AU - Gasparics, Ákos

PY - 2019/1/1

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N2 - Background: There are limited data available on the survival and early complications of preterm infants with less than 500 g birthweight. To estimate the outcomes for these infants, it is important for caregivers to be aware of perinatal factors that may affect survival. Objectives: We assessed the mortality and certain early complications of preterm infants born with less than 500 g in Hungary between 2006 and 2015. Methods: We reviewed data of 486 infants from the database of the Hungarian Central Statistical Office and in parallel of 407 infants from the “NICU database.” The study period was divided into two epochs: 2006-2010 and 2011-2015. Results: The survival was 27.1% in the first epoch and 39.1% in the second epoch, and the incidence of early complications was slightly higher in the second epoch. In the surviving group (first and second epoch combined), gestational age (25.1 vs 23.7 weeks), birthweight (458 vs 447 g) antenatal steroid treatment (66.3% vs 52.3%), surfactant therapy (95.1% vs 84.3%), median Apgar scores (6 vs 3 and 8 vs 5 at 1 and 5 minutes, respectively) and proportion of caesarean delivery (89.3% versus 68.5%) were higher than in the non-surviving group (first and second epoch combined). The proportion of multiple births was lower in the surviving group (15.7% vs 33.4%). Conclusions: Survival of infants with less than 500 g improved between 2006-2010 and 2011-2015 in Hungary. The slightly higher occurrence of early complications might be associated with improving survival.

AB - Background: There are limited data available on the survival and early complications of preterm infants with less than 500 g birthweight. To estimate the outcomes for these infants, it is important for caregivers to be aware of perinatal factors that may affect survival. Objectives: We assessed the mortality and certain early complications of preterm infants born with less than 500 g in Hungary between 2006 and 2015. Methods: We reviewed data of 486 infants from the database of the Hungarian Central Statistical Office and in parallel of 407 infants from the “NICU database.” The study period was divided into two epochs: 2006-2010 and 2011-2015. Results: The survival was 27.1% in the first epoch and 39.1% in the second epoch, and the incidence of early complications was slightly higher in the second epoch. In the surviving group (first and second epoch combined), gestational age (25.1 vs 23.7 weeks), birthweight (458 vs 447 g) antenatal steroid treatment (66.3% vs 52.3%), surfactant therapy (95.1% vs 84.3%), median Apgar scores (6 vs 3 and 8 vs 5 at 1 and 5 minutes, respectively) and proportion of caesarean delivery (89.3% versus 68.5%) were higher than in the non-surviving group (first and second epoch combined). The proportion of multiple births was lower in the surviving group (15.7% vs 33.4%). Conclusions: Survival of infants with less than 500 g improved between 2006-2010 and 2011-2015 in Hungary. The slightly higher occurrence of early complications might be associated with improving survival.

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