Surprising sequential effects on MMN

Jade D. Frost, I. Winkler, Alexander Provost, Juanita Todd

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The mismatch negativity (MMN) is conceptualized as a confidence-weighted error signal elicited when a deviation violates the predicted next-state based on regularity. The mechanisms underpinning its generation remain contentious. Smaller MMN response is a robust finding in schizophrenia and reduced amplitude may implicate impairment in prediction-error signalling. An enriched understanding of factors that influence MMN size in healthy people is a prerequisite for translating the relevance of reduced MMN in schizophrenia. This paper features two studies designed to explore factors that impact MMN in healthy individuals. Study 1 confirms that MMN amplitude does not faithfully reflect transition statistics and is susceptible to order-driven bias. In study 2, we demonstrate that an order-driven bias remains despite repeated encounters with sound sequences. These data demonstrate that factors that impact on MMN size in non-clinical groups are not fully understood and that some mechanisms driving relevance filtering are likely influenced by 'top-down' expectations.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalBiological Psychology
Volume116
DOIs
Publication statusPublished - Apr 1 2016

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Schizophrenia

Keywords

  • Auditory
  • Bias
  • Context
  • ERP
  • First-impressions
  • Mismatch negativity
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Surprising sequential effects on MMN. / Frost, Jade D.; Winkler, I.; Provost, Alexander; Todd, Juanita.

In: Biological Psychology, Vol. 116, 01.04.2016, p. 47-56.

Research output: Contribution to journalArticle

Frost, Jade D. ; Winkler, I. ; Provost, Alexander ; Todd, Juanita. / Surprising sequential effects on MMN. In: Biological Psychology. 2016 ; Vol. 116. pp. 47-56.
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