Surgical vagotomy and stomach wall ATP and ADP in pylorus-ligated rats

G. Mózsik, F. Vizi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The stomach wall ATP and ADP have been studied in rats, with and without bilateral surgical vagotomy, 24 hr after pylorus ligation. It was observed that the amounts and concentrations of ATP significantly decreased in both parts (corpus + antrum and forestomach) in pylorus-ligated rats, while the amounts and concentrations remained at a significantly higher level in pylorus-ligated+vagotomized rats. Changes in amounts and concentrations of ADP paralleled those of ATP. It has been concluded that a significant decrease of cellular ATP is necessary to produce gastric hypersecretion in ulceration in pylorus-ligated rats. This significant decrease of cellular ATP, in corpus + antrum and forestomach, can be prevented by bilateral surgical vagotomy.

Original languageEnglish
Pages (from-to)1072-1075
Number of pages4
JournalThe American Journal of Digestive Diseases
Volume22
Issue number12
DOIs
Publication statusPublished - 1977

Fingerprint

Vagotomy
Pylorus
Adenosine Diphosphate
Stomach
Adenosine Triphosphate
Ligation

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Surgical vagotomy and stomach wall ATP and ADP in pylorus-ligated rats. / Mózsik, G.; Vizi, F.

In: The American Journal of Digestive Diseases, Vol. 22, No. 12, 1977, p. 1072-1075.

Research output: Contribution to journalArticle

@article{74be031a58c34ecda67aa8b57f892870,
title = "Surgical vagotomy and stomach wall ATP and ADP in pylorus-ligated rats",
abstract = "The stomach wall ATP and ADP have been studied in rats, with and without bilateral surgical vagotomy, 24 hr after pylorus ligation. It was observed that the amounts and concentrations of ATP significantly decreased in both parts (corpus + antrum and forestomach) in pylorus-ligated rats, while the amounts and concentrations remained at a significantly higher level in pylorus-ligated+vagotomized rats. Changes in amounts and concentrations of ADP paralleled those of ATP. It has been concluded that a significant decrease of cellular ATP is necessary to produce gastric hypersecretion in ulceration in pylorus-ligated rats. This significant decrease of cellular ATP, in corpus + antrum and forestomach, can be prevented by bilateral surgical vagotomy.",
author = "G. M{\'o}zsik and F. Vizi",
year = "1977",
doi = "10.1007/BF01072860",
language = "English",
volume = "22",
pages = "1072--1075",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "12",

}

TY - JOUR

T1 - Surgical vagotomy and stomach wall ATP and ADP in pylorus-ligated rats

AU - Mózsik, G.

AU - Vizi, F.

PY - 1977

Y1 - 1977

N2 - The stomach wall ATP and ADP have been studied in rats, with and without bilateral surgical vagotomy, 24 hr after pylorus ligation. It was observed that the amounts and concentrations of ATP significantly decreased in both parts (corpus + antrum and forestomach) in pylorus-ligated rats, while the amounts and concentrations remained at a significantly higher level in pylorus-ligated+vagotomized rats. Changes in amounts and concentrations of ADP paralleled those of ATP. It has been concluded that a significant decrease of cellular ATP is necessary to produce gastric hypersecretion in ulceration in pylorus-ligated rats. This significant decrease of cellular ATP, in corpus + antrum and forestomach, can be prevented by bilateral surgical vagotomy.

AB - The stomach wall ATP and ADP have been studied in rats, with and without bilateral surgical vagotomy, 24 hr after pylorus ligation. It was observed that the amounts and concentrations of ATP significantly decreased in both parts (corpus + antrum and forestomach) in pylorus-ligated rats, while the amounts and concentrations remained at a significantly higher level in pylorus-ligated+vagotomized rats. Changes in amounts and concentrations of ADP paralleled those of ATP. It has been concluded that a significant decrease of cellular ATP is necessary to produce gastric hypersecretion in ulceration in pylorus-ligated rats. This significant decrease of cellular ATP, in corpus + antrum and forestomach, can be prevented by bilateral surgical vagotomy.

UR - http://www.scopus.com/inward/record.url?scp=0017753490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017753490&partnerID=8YFLogxK

U2 - 10.1007/BF01072860

DO - 10.1007/BF01072860

M3 - Article

C2 - 930905

AN - SCOPUS:0017753490

VL - 22

SP - 1072

EP - 1075

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 12

ER -