Chirurgická léčba a prognostické faktory u nádorového bujení obřích kostních buněk

Translated title of the contribution: Surgical treatment and prognostic factors in giant-cell tumor of bone

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The rate of local recurrence in the giant-cell tumor of bone (GCT) is influenced by many factors. GCT aggressiveness is related to mitotic activity, aneuploidy of tumor cells, chromosomal abnormality, excessive metalloproteinase expression and alterations in different oncogenes. Statistically, there was no correlation between the recurrence rate and the size and site of tumor, stage of disease and involvement of subchondral bone. However, statistical analysis revealed that the use of adjuvants (phenol, bone cement, etc) and the type of surgical intervention (en block resection versus curettage and grafting) were factors with a prognostic value. Although recurrence or malignant transformation in GCT cannot be predicted yet, about 96% of the patients can be cured. In the majority of cases, recurrences have no fatal consequences for the patient but may lead to various degrees of disability due to repeated and more radical surgical procedures. Joint-sparing surgery and careful curettage with the use of adjuvants should be the treatment of choice whenever possible. In the future, modern instruments of molecular biology will be used to aid the evaluation of primary and recurrent tumors and will have an increasing influence on surgical planning.

Translated title of the contributionSurgical treatment and prognostic factors in giant-cell tumor of bone
Original languageCzech
Pages (from-to)142-150
Number of pages9
JournalActa Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Volume70
Issue number3
Publication statusPublished - Jul 29 2003

Keywords

  • Adjuvant
  • Giant-cell tumor of bone
  • Prognostic factor
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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