Surface treatment of indomethacin agglomerates with Eudragit

János Bajdik, Klára Pintye-Hódi, Odon Planinšek, Zsófia Tüske, Ljiljana Tasic, Géza Regdon, Stane Srčič, István Eros

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14 Citations (Scopus)

Abstract

Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalDrug development and industrial pharmacy
Volume30
Issue number4
DOIs
Publication statusPublished - Jan 1 2004

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Keywords

  • Agglomerates
  • Coating
  • Eudragit NE
  • Indomethacin
  • Surface free energy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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