Surface treatment of dimenhydrinate crystals

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dimenhydrinate is a heat-sensitive antihistamine with a low melting point. The heat-sensitive feature is of importance if direct compression is used. Direct measurement of the heat originating in the texture of tablets during compression is very difficult. Thermoanalytical methods were used as indirect methods to describe the changes in material properties at high temperature: differential scanning calorimetry, thermomicroscopy and thermogravimetric analysis. Film coating method is widely used in pharmaceutical technology. A fluidized bed apparatus was applied to coat the crystals. The coating film forming agent was hydroxy-propyl-methylcellulose (HPMC), which is a gastric-soluble polymer. Thermoanalytical measurements reveal that dimenhydrinate crystals are sensitive to heat. Film coating method does not alter the shape of the DSC curve of dimenhydrinate, but increases the melting point. The presence of a macromolecular film reduces the thermal conductivity, because it separates the particles.

Original languageEnglish
Pages (from-to)797-807
Number of pages11
JournalJournal of Thermal Analysis and Calorimetry
Volume62
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

dimenhydrinate
Dimenhydrinate
surface treatment
Surface treatment
heat
Crystals
Coatings
crystals
melting points
Melting point
coating
tablets
Methylcellulose
Histamine Antagonists
Fluidized beds
Drug products
Tablets
Thermogravimetric analysis
beds
Differential scanning calorimetry

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Surface treatment of dimenhydrinate crystals. / Bajdik, J.; Pintye-Hódi, K.; Novák, C.; Szabó-Révész, P.; Regdon, G.; Erös, I.; Pokol, G.

In: Journal of Thermal Analysis and Calorimetry, Vol. 62, No. 3, 2000, p. 797-807.

Research output: Contribution to journalArticle

@article{7a91704468234e738faa3a1e43943393,
title = "Surface treatment of dimenhydrinate crystals",
abstract = "Dimenhydrinate is a heat-sensitive antihistamine with a low melting point. The heat-sensitive feature is of importance if direct compression is used. Direct measurement of the heat originating in the texture of tablets during compression is very difficult. Thermoanalytical methods were used as indirect methods to describe the changes in material properties at high temperature: differential scanning calorimetry, thermomicroscopy and thermogravimetric analysis. Film coating method is widely used in pharmaceutical technology. A fluidized bed apparatus was applied to coat the crystals. The coating film forming agent was hydroxy-propyl-methylcellulose (HPMC), which is a gastric-soluble polymer. Thermoanalytical measurements reveal that dimenhydrinate crystals are sensitive to heat. Film coating method does not alter the shape of the DSC curve of dimenhydrinate, but increases the melting point. The presence of a macromolecular film reduces the thermal conductivity, because it separates the particles.",
author = "J. Bajdik and K. Pintye-H{\'o}di and C. Nov{\'a}k and P. Szab{\'o}-R{\'e}v{\'e}sz and G. Regdon and I. Er{\"o}s and G. Pokol",
year = "2000",
doi = "10.1023/A:1012093929296",
language = "English",
volume = "62",
pages = "797--807",
journal = "Journal of Thermal Analysis and Calorimetry",
issn = "1388-6150",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Surface treatment of dimenhydrinate crystals

AU - Bajdik, J.

AU - Pintye-Hódi, K.

AU - Novák, C.

AU - Szabó-Révész, P.

AU - Regdon, G.

AU - Erös, I.

AU - Pokol, G.

PY - 2000

Y1 - 2000

N2 - Dimenhydrinate is a heat-sensitive antihistamine with a low melting point. The heat-sensitive feature is of importance if direct compression is used. Direct measurement of the heat originating in the texture of tablets during compression is very difficult. Thermoanalytical methods were used as indirect methods to describe the changes in material properties at high temperature: differential scanning calorimetry, thermomicroscopy and thermogravimetric analysis. Film coating method is widely used in pharmaceutical technology. A fluidized bed apparatus was applied to coat the crystals. The coating film forming agent was hydroxy-propyl-methylcellulose (HPMC), which is a gastric-soluble polymer. Thermoanalytical measurements reveal that dimenhydrinate crystals are sensitive to heat. Film coating method does not alter the shape of the DSC curve of dimenhydrinate, but increases the melting point. The presence of a macromolecular film reduces the thermal conductivity, because it separates the particles.

AB - Dimenhydrinate is a heat-sensitive antihistamine with a low melting point. The heat-sensitive feature is of importance if direct compression is used. Direct measurement of the heat originating in the texture of tablets during compression is very difficult. Thermoanalytical methods were used as indirect methods to describe the changes in material properties at high temperature: differential scanning calorimetry, thermomicroscopy and thermogravimetric analysis. Film coating method is widely used in pharmaceutical technology. A fluidized bed apparatus was applied to coat the crystals. The coating film forming agent was hydroxy-propyl-methylcellulose (HPMC), which is a gastric-soluble polymer. Thermoanalytical measurements reveal that dimenhydrinate crystals are sensitive to heat. Film coating method does not alter the shape of the DSC curve of dimenhydrinate, but increases the melting point. The presence of a macromolecular film reduces the thermal conductivity, because it separates the particles.

UR - http://www.scopus.com/inward/record.url?scp=0034481455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034481455&partnerID=8YFLogxK

U2 - 10.1023/A:1012093929296

DO - 10.1023/A:1012093929296

M3 - Article

AN - SCOPUS:0034481455

VL - 62

SP - 797

EP - 807

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

IS - 3

ER -