Surface properties of poly(lactic/glycolic acid) - Pluronic © blend films

E. Kiss, M. G. Takács, I. Bertóti, E. I. Vargha-Butler

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Poly(DL-lactide) (PLA) and two of its random copolymers with glycolic acid, poly(DL-lactide-co-glycolide) (PLGA) with 75/25 and 50/50 component ratios of lactide/glycolide were blended with poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) triblock non-ionic surfactants, known by the Pluronic® trade names of PE6100, PE6400 and PE6800. The surface chemical compositions of the blended films were identified by X-ray photoelectron spectroscopy (XPS). Based on the component of the carbon signal assigned to the ether carbon of the Pluronic® molecule, quantification of the surface accumulation of the Pluronic® additive, compared to its bulk concentration, was performed. The data demonstrated that PEO-containing surfaces were prepared by the blending process. A significant surface hydrophilization, characterized by wettability measurements, was obtained by applying the Pluronics® at a concentration of 1.0-9.1 wt% in the blends. The composition of the surface layer and, in accordance with this, the wettability of the film were found to be dependent on the type of Pluronic® and on the composition of the unmodified polymer. Protein adsorption on the polymer films was measured by the FT-IR ATR spectroscopic technique. The adsorbed amount of bovine serum albumin onto PLA was highly reduced when the polymer was blended with a Pluronic®. The increased hydrophilicity and the reduced protein adsorption properties of the PLA and PLGA obtained by blending with PEO compounds might contribute to their applications as drug carrier systems with great potential.

Original languageEnglish
Pages (from-to)839-846
Number of pages8
JournalPolymers for Advanced Technologies
Volume14
Issue number11-12
Publication statusPublished - Nov 2003

Fingerprint

glycolic acid
Poloxamer
Lactic acid
Surface properties
Polyethylene oxides
Wetting
Chemical analysis
Polymers
Proteins
Polypropylene oxides
Carbon
Adsorption
Trademarks
Nonionic surfactants
Hydrophilicity
Drug Carriers
Polymer films
Bovine Serum Albumin
Ethers
Ether

Keywords

  • Adsorption (protein)
  • Biocompatibility
  • Blends
  • ESCA/XPS
  • Wettability

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Surface properties of poly(lactic/glycolic acid) - Pluronic © blend films. / Kiss, E.; Takács, M. G.; Bertóti, I.; Vargha-Butler, E. I.

In: Polymers for Advanced Technologies, Vol. 14, No. 11-12, 11.2003, p. 839-846.

Research output: Contribution to journalArticle

Kiss, E. ; Takács, M. G. ; Bertóti, I. ; Vargha-Butler, E. I. / Surface properties of poly(lactic/glycolic acid) - Pluronic © blend films. In: Polymers for Advanced Technologies. 2003 ; Vol. 14, No. 11-12. pp. 839-846.
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