Módosított politejsav- és poli(tejsav/glikolsav)- filmek felületvizsgálata

Translated title of the contribution: Surface characterization of modified poly(lactic acid) and poly(lactic/glycolic acid) films by wettability and XPS technique

E. Kiss, I. Bertóti, Éva Vargha-Butler

Research output: Contribution to journalArticle

Abstract

Poly(lactic acid), PLA, and poly(lactic/glycolic acid) copolymers, PLGA, are biodegradable drug carriers of great importance, although successful pharmaceutical application requires adjustment of the surface properties of the polymeric drug delivery system to be compatible to the biological environment. For that reason, reduction of the original hydrophobicity of the PLA or PLGA surfaces was performed by applying a hydrophilic polymer poly(ethylene oxide), PEO with the aim to improve the biocompatibility of the original polymer. PEO containing surfaces were prepared by incorporation of block copolymeric surfactants, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), (Pluronic) into the hydrophobic surface. Films of polymer blends from PLA or PLGA (with lacric/glycolic acid ratio of 75/25 and 50/50) and from Pluronics (PE6800, PE6400 and PE6100) were obtained by solvent casting method applying the Pluronic at different concentrations between 1.0 and 9.1 w/w%. Wettability was measured to monitor the change of surface hydrophobicity, while X-ray photoelectron spectroscopy, XPS, was applied to determine the composition and chemical structure of the polymer surface and its change with surface modification. Substantial reduction of surface hydrophobicity was achieved on both PLA homopolymer and the PLGA copolymers applying the Pluronics at various concentrations. The degree of change in wettability was proportional to the surface concentration of the Pluronic additive. In accordance with the wettability changes the accumulation of Pluronic in the surface layer was greatly affected by the initial hydrophobicity of the polymer, namely by the lactide content of the copolymer. The extent of surface modification was also found to be dependent on the type of blended Pluronics. It was demonstrated, that the type of Pluronic and its appropriate concentration for modification of PLA or PLGA could be given to achieve a surface hydrophilization required. Compatibility, hydrophilization effect and surface activity of the modifying Pluronic component were interpreted by using the Flory-Huggins interaction parameters and the solubility parameters.

Original languageHungarian
Pages (from-to)263-272
Number of pages10
JournalMagyar Kemiai Folyoirat, Kemiai Kozlemenyek
Volume108
Issue number6
Publication statusPublished - Jun 2002

Fingerprint

glycolic acid
Poloxamer
Lactic acid
Wetting
X ray photoelectron spectroscopy
Hydrophobicity
Polymers
Polyethylene oxides
Copolymers
Surface treatment
poly(lactic acid)
Drug Carriers

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Módosított politejsav- és poli(tejsav/glikolsav)- filmek felületvizsgálata. / Kiss, E.; Bertóti, I.; Vargha-Butler, Éva.

In: Magyar Kemiai Folyoirat, Kemiai Kozlemenyek, Vol. 108, No. 6, 06.2002, p. 263-272.

Research output: Contribution to journalArticle

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abstract = "Poly(lactic acid), PLA, and poly(lactic/glycolic acid) copolymers, PLGA, are biodegradable drug carriers of great importance, although successful pharmaceutical application requires adjustment of the surface properties of the polymeric drug delivery system to be compatible to the biological environment. For that reason, reduction of the original hydrophobicity of the PLA or PLGA surfaces was performed by applying a hydrophilic polymer poly(ethylene oxide), PEO with the aim to improve the biocompatibility of the original polymer. PEO containing surfaces were prepared by incorporation of block copolymeric surfactants, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide), (Pluronic) into the hydrophobic surface. Films of polymer blends from PLA or PLGA (with lacric/glycolic acid ratio of 75/25 and 50/50) and from Pluronics (PE6800, PE6400 and PE6100) were obtained by solvent casting method applying the Pluronic at different concentrations between 1.0 and 9.1 w/w{\%}. Wettability was measured to monitor the change of surface hydrophobicity, while X-ray photoelectron spectroscopy, XPS, was applied to determine the composition and chemical structure of the polymer surface and its change with surface modification. Substantial reduction of surface hydrophobicity was achieved on both PLA homopolymer and the PLGA copolymers applying the Pluronics at various concentrations. The degree of change in wettability was proportional to the surface concentration of the Pluronic additive. In accordance with the wettability changes the accumulation of Pluronic in the surface layer was greatly affected by the initial hydrophobicity of the polymer, namely by the lactide content of the copolymer. The extent of surface modification was also found to be dependent on the type of blended Pluronics. It was demonstrated, that the type of Pluronic and its appropriate concentration for modification of PLA or PLGA could be given to achieve a surface hydrophilization required. Compatibility, hydrophilization effect and surface activity of the modifying Pluronic component were interpreted by using the Flory-Huggins interaction parameters and the solubility parameters.",
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