Supramolecular elucidation of the quality attributes of microcrystalline cellulose and isomalt composite pellet cores

I. Antal, Nikolett Kállai, Oliver Luhn, Jörg Bernard, Zsombor Kristóf Nagy, Barnabás Szabó, I. Klebovich, R. Zelkó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The major objective of this study was to disclose the relationships between the physical quality attributes and supramolecular structure of novel composite pellet cores containing microcrystalline cellulose (MCC) and isomalt in different ratios.The novel composite pellet cores were manufactured by an extrusion/spheronisation process. The micro or supramolecular structure of pellets was tracked by positron annihilation lifetime spectroscopy (PALS) based on the o-Ps lifetime values. The results indicate a correlation between the examined macro and microstructural properties of the inert cores. The higher free volume holes indicated by the higher o-Ps lifetime values resulted in a more mobile micro- and supramolecular structure of MCC cores thus increasing the plastic deformation and the tensile strength of the cores. A physical interaction was found between the microcrystalline cellulose and isomalt which supports the osmotic effect of the water soluble sugar alcohol in the composite pellet cores regarding drug release.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume84
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Composite materials
Sugar Alcohols
Positron annihilation
Tensile Strength
Free volume
Plastics
Extrusion
Macros
Plastic deformation
Spectrum Analysis
Tensile strength
Spectroscopy
Electrons
Water
Pharmaceutical Preparations
Palatinit
microcrystalline cellulose
Drug Liberation

Keywords

  • Inert pellet core
  • Isomalt
  • Microcrystalline cellulose
  • Positron annihilation lifetime spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Supramolecular elucidation of the quality attributes of microcrystalline cellulose and isomalt composite pellet cores. / Antal, I.; Kállai, Nikolett; Luhn, Oliver; Bernard, Jörg; Nagy, Zsombor Kristóf; Szabó, Barnabás; Klebovich, I.; Zelkó, R.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 84, 10.2013, p. 124-128.

Research output: Contribution to journalArticle

Antal, I. ; Kállai, Nikolett ; Luhn, Oliver ; Bernard, Jörg ; Nagy, Zsombor Kristóf ; Szabó, Barnabás ; Klebovich, I. ; Zelkó, R. / Supramolecular elucidation of the quality attributes of microcrystalline cellulose and isomalt composite pellet cores. In: Journal of Pharmaceutical and Biomedical Analysis. 2013 ; Vol. 84. pp. 124-128.
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