Suppression of food intake by intracerebroventricular injection of alpha-MSH varies with age in rats

E. Pétervári, M. Balaskó, A. Garami, Sz Soós, M. Székely

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

During the aging process of mammals first a phase of obesity and increased adiposity is observed in middle-aged subjects, then anorexia and loss of body weight (sarcopenia) at old age. A possible agedependence of the anorexigenic alpha-melanocyte-stimulating-hormone (alpha-MSH) in these regulatory changes was studied. Male Wistar rats aged 6-8 weeks (juvenile), 3-4 months (young adult), 6 and 12 months (middle-aged), and 24-26 months (old) were equipped with chronic cannula to the lateral cerebral ventricle. The effect of 5 μg alpha-MSH injected through the cannula was analyzed on food intake evoked by 24-h food deprivation. Juvenile rats seemed almost resistant to alpha-MSH (21.9% suppression). In young adults alpha-MSH suppressed food intake by 68.7%. However, the alpha-MSH-induced anorexia was significantly less pronounced in middle-aged (55.7% or 26.4% in rats aged 6 or 12 months, respectively), and much more pronounced (73.3%) in old rats. The adiposity (judged by the relative amount of perirenal fat) increased until middle-age, but did not change between middle-age and old-age. It is concluded that changes in alpha-MSH responsiveness possibly contribute to both the age-related obesity in middle-aged rats and to the anorexia of old ones: first the adiposity then the age may be the important factor.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalActa Physiologica Hungarica
Volume96
Issue number4
DOIs
Publication statusPublished - Dec 1 2009

Fingerprint

alpha-MSH
Eating
Injections
Adiposity
Anorexia
Young Adult
Obesity
Sarcopenia
Food Deprivation
Cerebral Ventricles
Lateral Ventricles
Wistar Rats
Mammals
Fats
Body Weight

Keywords

  • Aging
  • Alpha-MSH
  • Anorexia
  • Body composition
  • Body weight
  • Food intake
  • Obesity
  • Wistar rats

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Suppression of food intake by intracerebroventricular injection of alpha-MSH varies with age in rats. / Pétervári, E.; Balaskó, M.; Garami, A.; Soós, Sz; Székely, M.

In: Acta Physiologica Hungarica, Vol. 96, No. 4, 01.12.2009, p. 483-487.

Research output: Contribution to journalArticle

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