SUPPRESSION BY ORALLY‐ADMINISTERED NIFEDIPINE, NISOLDIPINE AND NILUDIPINE OF EARLY, LIFE‐THREATENING VENTRICULAR ARRHYTHMIAS RESULTING FROM ACUTE MYOCARDIAL ISCHAEMIA

O. FAGBEMI, J. R. PARRATT

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The oral administration to rats of the calcium antagonists nifedipine, nisoldipine and niludipine (3 mg/kg, 1 —1.25 h before acute coronary ligation) greatly reduced the duration of ventricular tachycardia and fibrillation (VF) occurring in the first 30min post‐ligation period. The duration of VF was especially reduced (by 74–92%). None of the animals so treated died compared with a 40% mortality in the controls. 1981 British Pharmacological Society

Original languageEnglish
Pages (from-to)12-14
Number of pages3
JournalBritish journal of pharmacology
Volume74
Issue number1
DOIs
Publication statusPublished - Sep 1981

ASJC Scopus subject areas

  • Pharmacology

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