Supercritical fluid extraction: A novel method for the resolution of tetramisole

S. Keszei, B. Simándi, Edit Székely, E. Fogassy, János Sawinsky, S. Kemény

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A new resolution method, based on the selective distribution of enantiomers between a chiral solid and an achiral supercritical fluid phase, is reported. The chiral solid phase is formed from the optically active dicarboxylic acid derivative, (2R,3R)-O,O'-dibenzoyltartaric acid, and the racemic base (tetramisole). A new method is also described for the enrichment of enantiomeric mixtures which have an enantiomeric ratio other than 1:1. This is based on the partial salt formation of the enantiomeric mixture with an achiral substance, which is then followed by supercritical fluid extraction of the free enantiomer. The extract has an enantiomeric composition which is different from the starting mixture. The method is applied to an enantiomeric mixture of tetramisole with hydrochloric acid.

Original languageEnglish
Pages (from-to)1275-1281
Number of pages7
JournalTetrahedron Asymmetry
Volume10
Issue number7
DOIs
Publication statusPublished - Apr 9 1999

Fingerprint

Tetramisole
Supercritical Fluid Chromatography
Supercritical fluid extraction
supercritical fluids
Supercritical fluids
Enantiomers
enantiomers
Dicarboxylic Acids
Hydrochloric Acid
Acids
dicarboxylic acids
hydrochloric acid
Hydrochloric acid
Salts
solid phases
salts
Derivatives
acids
Chemical analysis

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Supercritical fluid extraction : A novel method for the resolution of tetramisole. / Keszei, S.; Simándi, B.; Székely, Edit; Fogassy, E.; Sawinsky, János; Kemény, S.

In: Tetrahedron Asymmetry, Vol. 10, No. 7, 09.04.1999, p. 1275-1281.

Research output: Contribution to journalArticle

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