99mTc-MIBI SPECT assessment of the effects of aneurysm resection on the left ventricular morphology

Zsolt Koszegi, Rudolf Kolozsvari, J. Varga, L. Galuska, Tibor Szuk, Kalman Csapo, Tibor Fulop, Ida Hegedus, Dezsö Apro, Miklós Vaszily, Árpád Peterffy, I. Édes

Research output: Contribution to journalArticle

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Abstract

Objective - 99mTc-MIBI SPECT is a widely used myocardial perfusion investigation technique, but few data are available concerning its use to assess the morphological characteristics of a left ventricular aneurysm (LVA) before and after LVA resection. Methods and results - Pre- and postoperative rest 99mTc-MIBI SPECT images were analysed in order to characterize the features of LVAs and the changes in the 3D scintigraphic parameters after apical LVA resection in 6 patients. In the middle horizontal slice an angle was defined to quantify the apical divergence associated with the LVA. After resection, the changes in the divergence angles (DA) were measured as were the changes in the left ventricular volumes (LVV) by volumetric calculations. The mean DA decreased from an average of 38.5° ± 11.32° preoperatively to 24° ± 11.84° postoperatively (p = 0.03). The mean LVV also decreased significantly: from 443 ± 87 ml to 317 ± 74 ml (p = 0.003). The resectable LVAs were associated with a very low isotope uptake in the apical segments (<20% relative activity). A DA <20° was also characteristic of anatomical LVA in all patients. A regression curve plotting divergence angle and the number of left ventricular segments below 20% relative activity showed a significant correlation between them (r = 0.86, p = 0.003). Conclusions - The significant decreases of DA and LVV after resection reflect favourable morphological changes in the left ventricle (reverse remodelling). We consider 99mTc-MIBI SPECT a useful method for apical LVA detection, it allows an analysis of the morphological (and indirectly the functional) results of the surgery.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalActa Cardiologica
Volume59
Issue number5
DOIs
Publication statusPublished - Oct 2004

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Single-Photon Emission-Computed Tomography
Aneurysm
Ventricular Remodeling
Isotopes
Perfusion

Keywords

  • 3D morphology
  • MIBI SPECT
  • Aneurysm resection
  • Left ventricular aneurysm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

99mTc-MIBI SPECT assessment of the effects of aneurysm resection on the left ventricular morphology. / Koszegi, Zsolt; Kolozsvari, Rudolf; Varga, J.; Galuska, L.; Szuk, Tibor; Csapo, Kalman; Fulop, Tibor; Hegedus, Ida; Apro, Dezsö; Vaszily, Miklós; Peterffy, Árpád; Édes, I.

In: Acta Cardiologica, Vol. 59, No. 5, 10.2004, p. 541-546.

Research output: Contribution to journalArticle

Koszegi, Z, Kolozsvari, R, Varga, J, Galuska, L, Szuk, T, Csapo, K, Fulop, T, Hegedus, I, Apro, D, Vaszily, M, Peterffy, Á & Édes, I 2004, '99mTc-MIBI SPECT assessment of the effects of aneurysm resection on the left ventricular morphology', Acta Cardiologica, vol. 59, no. 5, pp. 541-546. https://doi.org/10.2143/AC.59.5.2005230
Koszegi, Zsolt ; Kolozsvari, Rudolf ; Varga, J. ; Galuska, L. ; Szuk, Tibor ; Csapo, Kalman ; Fulop, Tibor ; Hegedus, Ida ; Apro, Dezsö ; Vaszily, Miklós ; Peterffy, Árpád ; Édes, I. / 99mTc-MIBI SPECT assessment of the effects of aneurysm resection on the left ventricular morphology. In: Acta Cardiologica. 2004 ; Vol. 59, No. 5. pp. 541-546.
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T1 - 99mTc-MIBI SPECT assessment of the effects of aneurysm resection on the left ventricular morphology

AU - Koszegi, Zsolt

AU - Kolozsvari, Rudolf

AU - Varga, J.

AU - Galuska, L.

AU - Szuk, Tibor

AU - Csapo, Kalman

AU - Fulop, Tibor

AU - Hegedus, Ida

AU - Apro, Dezsö

AU - Vaszily, Miklós

AU - Peterffy, Árpád

AU - Édes, I.

PY - 2004/10

Y1 - 2004/10

N2 - Objective - 99mTc-MIBI SPECT is a widely used myocardial perfusion investigation technique, but few data are available concerning its use to assess the morphological characteristics of a left ventricular aneurysm (LVA) before and after LVA resection. Methods and results - Pre- and postoperative rest 99mTc-MIBI SPECT images were analysed in order to characterize the features of LVAs and the changes in the 3D scintigraphic parameters after apical LVA resection in 6 patients. In the middle horizontal slice an angle was defined to quantify the apical divergence associated with the LVA. After resection, the changes in the divergence angles (DA) were measured as were the changes in the left ventricular volumes (LVV) by volumetric calculations. The mean DA decreased from an average of 38.5° ± 11.32° preoperatively to 24° ± 11.84° postoperatively (p = 0.03). The mean LVV also decreased significantly: from 443 ± 87 ml to 317 ± 74 ml (p = 0.003). The resectable LVAs were associated with a very low isotope uptake in the apical segments (<20% relative activity). A DA <20° was also characteristic of anatomical LVA in all patients. A regression curve plotting divergence angle and the number of left ventricular segments below 20% relative activity showed a significant correlation between them (r = 0.86, p = 0.003). Conclusions - The significant decreases of DA and LVV after resection reflect favourable morphological changes in the left ventricle (reverse remodelling). We consider 99mTc-MIBI SPECT a useful method for apical LVA detection, it allows an analysis of the morphological (and indirectly the functional) results of the surgery.

AB - Objective - 99mTc-MIBI SPECT is a widely used myocardial perfusion investigation technique, but few data are available concerning its use to assess the morphological characteristics of a left ventricular aneurysm (LVA) before and after LVA resection. Methods and results - Pre- and postoperative rest 99mTc-MIBI SPECT images were analysed in order to characterize the features of LVAs and the changes in the 3D scintigraphic parameters after apical LVA resection in 6 patients. In the middle horizontal slice an angle was defined to quantify the apical divergence associated with the LVA. After resection, the changes in the divergence angles (DA) were measured as were the changes in the left ventricular volumes (LVV) by volumetric calculations. The mean DA decreased from an average of 38.5° ± 11.32° preoperatively to 24° ± 11.84° postoperatively (p = 0.03). The mean LVV also decreased significantly: from 443 ± 87 ml to 317 ± 74 ml (p = 0.003). The resectable LVAs were associated with a very low isotope uptake in the apical segments (<20% relative activity). A DA <20° was also characteristic of anatomical LVA in all patients. A regression curve plotting divergence angle and the number of left ventricular segments below 20% relative activity showed a significant correlation between them (r = 0.86, p = 0.003). Conclusions - The significant decreases of DA and LVV after resection reflect favourable morphological changes in the left ventricle (reverse remodelling). We consider 99mTc-MIBI SPECT a useful method for apical LVA detection, it allows an analysis of the morphological (and indirectly the functional) results of the surgery.

KW - 3D morphology

KW - MIBI SPECT

KW - Aneurysm resection

KW - Left ventricular aneurysm

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