99mTc-labeling and biodistribution studies of some dihydro-1,4-thiazine and 1,3-thiazolidine-carboxylic acid derivatives

J. Környei, F. Sztaricskai, Z. Györgydeák, J. Pitlik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cephalosporanic acids (CEPHAs) such as dihydro-1,4-thiazine derivatives and 2-hydroxyalkyl-1,3-thiazolidine-4-carboxylic-acids, (HOTCAs) are both important biologically active molecules and complexing agents for several metals such as Fe, Zn, Pb, etc. The simplest way for the study of the effect of complex formation upon the biochemistry of these compounds requires radiolabeled complexes. As99mTc radioisotope gives the best opportunity for imaging the in vivo process,99mTc-CEPHAs and HOTCAs were prepared and investigated. It was found that biologically active molecules like CEPHAs and HOTCAs can be labeled with99mTc with good radiochemical yields. In case of one CEPHA compound, low but definite myocardial uptake was observed, while 3 of the HOTCAs showed characteristic renal uptake and wash-out without visualization of any other organs than the urinary tract.

Original languageEnglish
Pages (from-to)75-87
Number of pages13
JournalJournal of Radioanalytical and Nuclear Chemistry Letters
Volume186
Issue number1
DOIs
Publication statusPublished - Jan 1 1994

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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