[3H]Noradrenaline release evoked by selegiline ((‐)‐deprenyl) in the isolated main pulmonary artery of the rabbit*

Tamás L. Török, Zsuzsanna Bunyevácz, Tinh Thi Nguyen, Kálmán Magyar

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Abstract

High concentrations of selegiline((‐)‐deprenyl) (> 10−5 m) enhanced the nerve stimulation (2 Hz)‐evoked release of [3H]noradrenaline from the isolated main pulmonary artery of the rabbit. This facilitation of stimulation‐evoked [3H]noradrenaline release by selegiline was reduced by exogenous (‐)‐noradrenaline, an agonist of presynaptic α2‐adrenoceptors. This inhibitory action of (‐)‐noradrenaline was partly antagonized by yohimbine, a selective α2‐adrenoceptor blocker. When the stimulation‐evoked [3H]noradrenaline release had already been incresed by inhibition of Na+‐pump (K+‐free solution), selegiline further enhanced the nerve‐evoked release of labelled neurotransmitter. 1984 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 1984

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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