13C-Urea breath test is superior in sensitivity to detect Helicobacter pylori infection than either antral histology or rapid urease test

G. Sütö, A. Vincze, Ferenc Pakodi, B. Hunyady, Oszkár Karádi, Mária Garamszegi, Terézia László, G. Mózsik

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

There is no single technique which fulfills the criterion for a reference method to detect Helicobacter pylori (Hp) infection. The aim was to compare the results of antral histology (H), rapid urease test (U) and urea breath test (UBT) from antral biopsy samples in patients having gastric or duodenal lesions during upper GI endoscopy. We used the following methods: 1) biopsy specimens for histology (Warthin-Starry staining); 2) rapid urease test; and 3) 11C-urea breath test with infrared spectrometry. The total number of patients was 166 examined by H, U, and UBT. H, U and UBT were negative (-) in 64 patients and positive(+) in 51. The true positivity and false negativity (%, number of patients in parentheses) of each method based upon the positivity of the other two tests were: H+, U+ (54): UBT+, 94.4% (51) and UBT-, 5.6% (3); H+, UBT+ (57): U+, 89.5% (51) and U-, 10.5% (6); U+, UBT+(65): H+, 78.5% (51) and H-, 21.5% (14). If Hp infection is considered to be positive when at least two tests detect the presence of Hp, UBT shows the highest sensitivity in comparison to histology of biopsy specimens and urease test. UBT is highly recommended as a screening test for Hp infection in patients presenting upper GI endoscopic alterations. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalJournal of Physiology Paris
Volume94
Issue number2
DOIs
Publication statusPublished - Mar 2000

Fingerprint

Breath Tests
Urease
Helicobacter Infections
Helicobacter pylori
Urea
Histology
Biopsy
Antral
Endoscopy
Spectrum Analysis
Stomach
Staining and Labeling

Keywords

  • Helicobacter pylori
  • Histology
  • Rapid urease test
  • Urea breath test

ASJC Scopus subject areas

  • Physiology (medical)
  • Neuroscience(all)

Cite this

13C-Urea breath test is superior in sensitivity to detect Helicobacter pylori infection than either antral histology or rapid urease test. / Sütö, G.; Vincze, A.; Pakodi, Ferenc; Hunyady, B.; Karádi, Oszkár; Garamszegi, Mária; László, Terézia; Mózsik, G.

In: Journal of Physiology Paris, Vol. 94, No. 2, 03.2000, p. 153-156.

Research output: Contribution to journalArticle

@article{5fcaf5341bd748aebadb8b0f5eaf50b2,
title = "13C-Urea breath test is superior in sensitivity to detect Helicobacter pylori infection than either antral histology or rapid urease test",
abstract = "There is no single technique which fulfills the criterion for a reference method to detect Helicobacter pylori (Hp) infection. The aim was to compare the results of antral histology (H), rapid urease test (U) and urea breath test (UBT) from antral biopsy samples in patients having gastric or duodenal lesions during upper GI endoscopy. We used the following methods: 1) biopsy specimens for histology (Warthin-Starry staining); 2) rapid urease test; and 3) 11C-urea breath test with infrared spectrometry. The total number of patients was 166 examined by H, U, and UBT. H, U and UBT were negative (-) in 64 patients and positive(+) in 51. The true positivity and false negativity ({\%}, number of patients in parentheses) of each method based upon the positivity of the other two tests were: H+, U+ (54): UBT+, 94.4{\%} (51) and UBT-, 5.6{\%} (3); H+, UBT+ (57): U+, 89.5{\%} (51) and U-, 10.5{\%} (6); U+, UBT+(65): H+, 78.5{\%} (51) and H-, 21.5{\%} (14). If Hp infection is considered to be positive when at least two tests detect the presence of Hp, UBT shows the highest sensitivity in comparison to histology of biopsy specimens and urease test. UBT is highly recommended as a screening test for Hp infection in patients presenting upper GI endoscopic alterations. (C) 2000 Elsevier Science Ltd.",
keywords = "Helicobacter pylori, Histology, Rapid urease test, Urea breath test",
author = "G. S{\"u}t{\"o} and A. Vincze and Ferenc Pakodi and B. Hunyady and Oszk{\'a}r Kar{\'a}di and M{\'a}ria Garamszegi and Ter{\'e}zia L{\'a}szl{\'o} and G. M{\'o}zsik",
year = "2000",
month = "3",
doi = "10.1016/S0928-4257(00)00157-1",
language = "English",
volume = "94",
pages = "153--156",
journal = "Journal de Physiologie",
issn = "0928-4257",
publisher = "Elsevier Masson SAS",
number = "2",

}

TY - JOUR

T1 - 13C-Urea breath test is superior in sensitivity to detect Helicobacter pylori infection than either antral histology or rapid urease test

AU - Sütö, G.

AU - Vincze, A.

AU - Pakodi, Ferenc

AU - Hunyady, B.

AU - Karádi, Oszkár

AU - Garamszegi, Mária

AU - László, Terézia

AU - Mózsik, G.

PY - 2000/3

Y1 - 2000/3

N2 - There is no single technique which fulfills the criterion for a reference method to detect Helicobacter pylori (Hp) infection. The aim was to compare the results of antral histology (H), rapid urease test (U) and urea breath test (UBT) from antral biopsy samples in patients having gastric or duodenal lesions during upper GI endoscopy. We used the following methods: 1) biopsy specimens for histology (Warthin-Starry staining); 2) rapid urease test; and 3) 11C-urea breath test with infrared spectrometry. The total number of patients was 166 examined by H, U, and UBT. H, U and UBT were negative (-) in 64 patients and positive(+) in 51. The true positivity and false negativity (%, number of patients in parentheses) of each method based upon the positivity of the other two tests were: H+, U+ (54): UBT+, 94.4% (51) and UBT-, 5.6% (3); H+, UBT+ (57): U+, 89.5% (51) and U-, 10.5% (6); U+, UBT+(65): H+, 78.5% (51) and H-, 21.5% (14). If Hp infection is considered to be positive when at least two tests detect the presence of Hp, UBT shows the highest sensitivity in comparison to histology of biopsy specimens and urease test. UBT is highly recommended as a screening test for Hp infection in patients presenting upper GI endoscopic alterations. (C) 2000 Elsevier Science Ltd.

AB - There is no single technique which fulfills the criterion for a reference method to detect Helicobacter pylori (Hp) infection. The aim was to compare the results of antral histology (H), rapid urease test (U) and urea breath test (UBT) from antral biopsy samples in patients having gastric or duodenal lesions during upper GI endoscopy. We used the following methods: 1) biopsy specimens for histology (Warthin-Starry staining); 2) rapid urease test; and 3) 11C-urea breath test with infrared spectrometry. The total number of patients was 166 examined by H, U, and UBT. H, U and UBT were negative (-) in 64 patients and positive(+) in 51. The true positivity and false negativity (%, number of patients in parentheses) of each method based upon the positivity of the other two tests were: H+, U+ (54): UBT+, 94.4% (51) and UBT-, 5.6% (3); H+, UBT+ (57): U+, 89.5% (51) and U-, 10.5% (6); U+, UBT+(65): H+, 78.5% (51) and H-, 21.5% (14). If Hp infection is considered to be positive when at least two tests detect the presence of Hp, UBT shows the highest sensitivity in comparison to histology of biopsy specimens and urease test. UBT is highly recommended as a screening test for Hp infection in patients presenting upper GI endoscopic alterations. (C) 2000 Elsevier Science Ltd.

KW - Helicobacter pylori

KW - Histology

KW - Rapid urease test

KW - Urea breath test

UR - http://www.scopus.com/inward/record.url?scp=0033624689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033624689&partnerID=8YFLogxK

U2 - 10.1016/S0928-4257(00)00157-1

DO - 10.1016/S0928-4257(00)00157-1

M3 - Article

C2 - 10791697

AN - SCOPUS:0033624689

VL - 94

SP - 153

EP - 156

JO - Journal de Physiologie

JF - Journal de Physiologie

SN - 0928-4257

IS - 2

ER -