[11C]-labeling of some caffeine derivatives for mapping adenosine A(2a) receptors by PET technique

I. Boros, G. Horvath, S. Lehel, T. Márián, Z. Kovacs, J. Szentmiklosi, G. Toth, L. Trón

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

[11C]-labeled form of ten A(2a) adenosine receptor specific 8-styryl- 7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N- methylation of the corresponding 8-styryl-xanthine derivatives using [11C]- methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35-93%), and can be utilised easily in online preparations. These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A(2a) receptors.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume242
Issue number2
DOIs
Publication statusPublished - 1999

Fingerprint

Adenosine A2A Receptors
Caffeine
Xanthine
Methylation
Positrons
Labeling
Electrons
Derivatives
Ligands
methyl iodide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

Cite this

[11C]-labeling of some caffeine derivatives for mapping adenosine A(2a) receptors by PET technique. / Boros, I.; Horvath, G.; Lehel, S.; Márián, T.; Kovacs, Z.; Szentmiklosi, J.; Toth, G.; Trón, L.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 242, No. 2, 1999, p. 309-312.

Research output: Contribution to journalArticle

Boros, I. ; Horvath, G. ; Lehel, S. ; Márián, T. ; Kovacs, Z. ; Szentmiklosi, J. ; Toth, G. ; Trón, L. / [11C]-labeling of some caffeine derivatives for mapping adenosine A(2a) receptors by PET technique. In: Journal of Radioanalytical and Nuclear Chemistry. 1999 ; Vol. 242, No. 2. pp. 309-312.
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AU - Kovacs, Z.

AU - Szentmiklosi, J.

AU - Toth, G.

AU - Trón, L.

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