Suitability of oligopeptides for induction of hormonal imprinting-implications on receptor and hormone evolution

G. Csaba, P. Kovács, Ottilia Török, Edit Bohdaneczky, S. Bajusz

Research output: Contribution to journalArticle

9 Citations (Scopus)


Hormonal imprinting induced in Tetrahymena and in Chang liver cells with di-, tri-, tetra- and pentapeptides (synthetic opioids and their fragments) has shown that both cell types are able to differentiate the related molecules from one another. The dipeptide phenylalanine + proline induced a measurable imprinting in the liver cells, and chain length increase, especially terminal coupling with tyrosine enhanced the imprinting potential enormously. Intra-chain changes in the amino acid sequence had a measurable effect on the intensity of imprinting. The molecules showing the relatively strongest physiological action accounted for the most intensive imprinting in both cell types; this indicates that, in all probability, induction of binding site formation plays a key role in the development of signal molecules, and thereby in hormone evolution.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
Issue number4
Publication statusPublished - 1986



  • Binding sites
  • Hormone evolution
  • Opioid peptides
  • Receptor phylogeny
  • Tetrahymena
  • Unicellular model

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

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