Suitability of oligopeptides for induction of hormonal imprinting-implications on receptor and hormone evolution

G. Csaba, P. Kovács, Ottilia Török, Edit Bohdaneczky, S. Bajusz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hormonal imprinting induced in Tetrahymena and in Chang liver cells with di-, tri-, tetra- and pentapeptides (synthetic opioids and their fragments) has shown that both cell types are able to differentiate the related molecules from one another. The dipeptide phenylalanine + proline induced a measurable imprinting in the liver cells, and chain length increase, especially terminal coupling with tyrosine enhanced the imprinting potential enormously. Intra-chain changes in the amino acid sequence had a measurable effect on the intensity of imprinting. The molecules showing the relatively strongest physiological action accounted for the most intensive imprinting in both cell types; this indicates that, in all probability, induction of binding site formation plays a key role in the development of signal molecules, and thereby in hormone evolution.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalBioSystems
Volume19
Issue number4
DOIs
Publication statusPublished - 1986

Fingerprint

oligopeptides
Oligopeptides
imprinting
genomic imprinting
Hormones
Receptor
hormone
Proof by induction
hormones
Liver
receptors
Molecules
Cell
Dipeptides
hepatocytes
Opioids
Binding sites
Phenylalanine
Chain length
Tetrahymena

Keywords

  • Binding sites
  • Hormone evolution
  • Opioid peptides
  • Receptor phylogeny
  • Tetrahymena
  • Unicellular model

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology
  • Drug Discovery

Cite this

Suitability of oligopeptides for induction of hormonal imprinting-implications on receptor and hormone evolution. / Csaba, G.; Kovács, P.; Török, Ottilia; Bohdaneczky, Edit; Bajusz, S.

In: BioSystems, Vol. 19, No. 4, 1986, p. 285-288.

Research output: Contribution to journalArticle

Csaba, G. ; Kovács, P. ; Török, Ottilia ; Bohdaneczky, Edit ; Bajusz, S. / Suitability of oligopeptides for induction of hormonal imprinting-implications on receptor and hormone evolution. In: BioSystems. 1986 ; Vol. 19, No. 4. pp. 285-288.
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