Suggested roles for microRNA in tumors

Pál Perge, Zoltán Nagy, Ivan Igaz, Peter Igaz

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

MicroRNAs are short non-coding RNA molecules encoded by distinct genes involved in the posttranscriptional regulation of gene expression. Forming part of the epigenetic machinery, microRNAs are involved in several aspects of tumorigenesis. Deregulation of microRNA expression is a common feature of tumors. Overexpressed oncogenic and underexpressed tumor suppressor microRNAs have been described in many different tumors. MicroRNAs are released from tumors that might affect other cells within and outside the tumor. Circulating microRNAs might also be involved in a tumor surveillance mechanism. In this short overview, some important aspects of microRNA in tumors are discussed.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalBiomolecular Concepts
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Keywords

  • circulating
  • epigenetic
  • membrane vesicle
  • microRNA
  • oncogene
  • tumor
  • tumor suppressor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

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