Sugar amino acid containing somatostatin analogues that induce apoptosis in both drug-sensitive and multidrug-resistant tumor cells

Sibylle A.W. Grunner, Gyorgy Kéri, Richard Schwab, Aniko Venetianer, Horst Kessler

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Figure presented Resistance to chemotherapy has become a major problem in cancer therapy. The new sugar amino acid (SAA) containing somatostatin analogues presented possess antiproliferative and apoptotic activity against both multidrug-resistant and drug-sensitive hepatoma carcinoma cells. Synthesis, design, and biological evaluation of the cyclic analogues and of the furanoid SAA used will be discussed. Four analogues have IC50 values in the low μM range, making them promising leads for chemotherapeutic drugs against multidrug-resistant carcinoma.

Original languageEnglish
Pages (from-to)3723-3725
Number of pages3
JournalOrganic Letters
Volume3
Issue number23
DOIs
Publication statusPublished - Nov 15 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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