Suckling-induced increase in cyclic AMP exclusively in the central region of the rat adenohypophysis

Katalin M. Horváth, Anikó Somogyvári-Vigh, Zoltán Kandár, Miklós Vecsernyés, Akira Arimura, György M. Nagy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Investigating the cellular events in the pituitary gland, the intracellular cyclic AMP (cAMP) of the neural lobe (NL), intermediate lobe (IL), the inner (IZ-AL) and outer zone (OZ-AL) of the anterior lobe (AL) have been measured during the suckling stimulus. Ten-minutes suckling, parallel to the elevation of plasma PRL, induced a significant increase of cAMP concentration in the IZ-AL. In contrast, 10- and 30-min suckling resulted in a decrease of cAMP level in the NL. Changes in cAMP of the OZ-AL and the IL as well as in the plasma level of α-MSH could not be detected. These region-specific changes of cAMP in the pituitary gland during suckling stimulus seems to be related to interacting neuroendocrine signals delivered concomitantly from the hypothalamus and from the NIL to the IZ-AL. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalBrain research
Volume873
Issue number1
DOIs
Publication statusPublished - Aug 4 2000

Keywords

  • Cyclic AMP
  • Inner zone of adenohypophysis
  • Prolactin
  • Suckling stimulus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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