Az alpha-melanocyta-stimuláló hormon és oxytocin elválasztásának és lokális transzportjának vizsgálata szopási inger hatására a hypophysis különbözo régióiban és az eminencia medianaban

Translated title of the contribution: Suckling-induced changes in oxytocin and alpha-melanocyte-stimulating hormone contents of the median eminence and various lokes of the pituitary gland

M. Vecsernyés, G. Nagy, L. Mészáros, I. Bodnár, A. Khalil Walid, R. Tóth, J. Julesz, Gy Nagy

Research output: Contribution to journalArticle

Abstract

Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the NIL, is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood arriving from the posterior pituitary through the short portal vessels (SPV) baths it first. Based on these facts it would be hypothesized that the locally released and/or produced important compounds, like oxytocin (OXT) and alpha-melanocyte-stimulating hormone (alpha-MSH), can be delivered to the AL-IZ. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into various regions of the pituitary gland (adenohypophysis innerzone (AL-IZ), outer zone (AL-OZ), intermediate lobe (IL), neural lobe (NL)) and median eminence of lactating rats. We have measured the concentration of OXT and alpha-MSH from tissue samples of nonsuckled and suckled rats using specific RIA-s. There were no changes in the concentration of OXY and alpha-MSH in the AL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXT is transported into the IL, which can be further increased by suckling stimulus. Our data have shown a lack of local delivery of either alpha-MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.

Original languageHungarian
Pages (from-to)201-204
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume71
Issue number2
Publication statusPublished - 2001

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alpha-MSH
Median Eminence
Pituitary Gland
Oxytocin
Prolactin
Posterior Pituitary Gland
Anterior Pituitary Gland
Baths
Hormones

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

@article{409e59c3de0c4ea5b4adf9e68c7c8370,
title = "Az alpha-melanocyta-stimul{\'a}l{\'o} hormon {\'e}s oxytocin elv{\'a}laszt{\'a}s{\'a}nak {\'e}s lok{\'a}lis transzportj{\'a}nak vizsg{\'a}lata szop{\'a}si inger hat{\'a}s{\'a}ra a hypophysis k{\"u}l{\"o}nb{\"o}zo r{\'e}gi{\'o}iban {\'e}s az eminencia medianaban",
abstract = "Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the NIL, is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood arriving from the posterior pituitary through the short portal vessels (SPV) baths it first. Based on these facts it would be hypothesized that the locally released and/or produced important compounds, like oxytocin (OXT) and alpha-melanocyte-stimulating hormone (alpha-MSH), can be delivered to the AL-IZ. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into various regions of the pituitary gland (adenohypophysis innerzone (AL-IZ), outer zone (AL-OZ), intermediate lobe (IL), neural lobe (NL)) and median eminence of lactating rats. We have measured the concentration of OXT and alpha-MSH from tissue samples of nonsuckled and suckled rats using specific RIA-s. There were no changes in the concentration of OXY and alpha-MSH in the AL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXT is transported into the IL, which can be further increased by suckling stimulus. Our data have shown a lack of local delivery of either alpha-MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.",
author = "M. Vecserny{\'e}s and G. Nagy and L. M{\'e}sz{\'a}ros and I. Bodn{\'a}r and {Khalil Walid}, A. and R. T{\'o}th and J. Julesz and Gy Nagy",
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language = "Hungarian",
volume = "71",
pages = "201--204",
journal = "Acta Pharmaceutica Hungarica",
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TY - JOUR

T1 - Az alpha-melanocyta-stimuláló hormon és oxytocin elválasztásának és lokális transzportjának vizsgálata szopási inger hatására a hypophysis különbözo régióiban és az eminencia medianaban

AU - Vecsernyés, M.

AU - Nagy, G.

AU - Mészáros, L.

AU - Bodnár, I.

AU - Khalil Walid, A.

AU - Tóth, R.

AU - Julesz, J.

AU - Nagy, Gy

PY - 2001

Y1 - 2001

N2 - Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the NIL, is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood arriving from the posterior pituitary through the short portal vessels (SPV) baths it first. Based on these facts it would be hypothesized that the locally released and/or produced important compounds, like oxytocin (OXT) and alpha-melanocyte-stimulating hormone (alpha-MSH), can be delivered to the AL-IZ. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into various regions of the pituitary gland (adenohypophysis innerzone (AL-IZ), outer zone (AL-OZ), intermediate lobe (IL), neural lobe (NL)) and median eminence of lactating rats. We have measured the concentration of OXT and alpha-MSH from tissue samples of nonsuckled and suckled rats using specific RIA-s. There were no changes in the concentration of OXY and alpha-MSH in the AL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXT is transported into the IL, which can be further increased by suckling stimulus. Our data have shown a lack of local delivery of either alpha-MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.

AB - Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the NIL, is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood arriving from the posterior pituitary through the short portal vessels (SPV) baths it first. Based on these facts it would be hypothesized that the locally released and/or produced important compounds, like oxytocin (OXT) and alpha-melanocyte-stimulating hormone (alpha-MSH), can be delivered to the AL-IZ. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into various regions of the pituitary gland (adenohypophysis innerzone (AL-IZ), outer zone (AL-OZ), intermediate lobe (IL), neural lobe (NL)) and median eminence of lactating rats. We have measured the concentration of OXT and alpha-MSH from tissue samples of nonsuckled and suckled rats using specific RIA-s. There were no changes in the concentration of OXY and alpha-MSH in the AL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXT is transported into the IL, which can be further increased by suckling stimulus. Our data have shown a lack of local delivery of either alpha-MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.

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