Suckling-induced change in oxytocin but not in α-MSH concentrations of the median eminence, the neural-, intermediate- and anterior lobes of the pituitary gland

M. Vecsernyés, G. Nagy, L. Meszaros, L. Bodnar, K. W. Ahmed, R. Tóth, J. Julesz, G. M. Nagy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the neuro-intermediate lobe (NIL), is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Whereas the outer-zone (AL-OZ) gives the basal secretion and it does not play a role in the acute secretory response during nursing. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood passing through the short portal vessels (SPV) bathes it first. Based on this fact it would be hypothesized that locally released and/or produced compounds, like OXY and a-MSH, can be delivered to the AL-IZ. In conjunction, OXY and a-MSH have already been implicated to play a role in the regulation of PRL release during suckling. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into the median eminence and various regions of the pituitary gland of lactating rats. We have measured the concentrations of OXY and α-MSH from tissue samples of nonsuckled (NS) and 10 or 30 min after suckling (S) was initiated using specific RIAs. It has been shown that there are no changes in the concentration of OXY and α-MSH in the AL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXY is transported into the IL, which can be further increased by suckling stimulus. These data suggest that blood transfusing NL passes through the IL before it is drained into the cavernous sinus, which opens the road for OXY into the general circulation. In addition, our data have unequivocally shown a lack of local delivery of either α MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.

Original languageEnglish
Pages (from-to)333-345
Number of pages13
JournalEndocrine Research
Volume26
Issue number3
Publication statusPublished - 2000

Fingerprint

Intermediate Pituitary Gland
Melanocyte-Stimulating Hormones
Median Eminence
Anterior Pituitary Gland
Oxytocin
Prolactin
Pituitary Gland
Cavernous Sinus
Nursing
Hormones

ASJC Scopus subject areas

  • Endocrinology

Cite this

Suckling-induced change in oxytocin but not in α-MSH concentrations of the median eminence, the neural-, intermediate- and anterior lobes of the pituitary gland. / Vecsernyés, M.; Nagy, G.; Meszaros, L.; Bodnar, L.; Ahmed, K. W.; Tóth, R.; Julesz, J.; Nagy, G. M.

In: Endocrine Research, Vol. 26, No. 3, 2000, p. 333-345.

Research output: Contribution to journalArticle

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abstract = "Previous reports have implicated that pituitary-derived prolactin (PRL) is secreted from two distinct zones of mammotropes within the anterior lobe (AL). The inner zone (AL-IZ), located adjacent to the neuro-intermediate lobe (NIL), is supposed to be involved in the rapid and massive discharge of PRL from the pituitary gland due to suckling stimulus. Whereas the outer-zone (AL-OZ) gives the basal secretion and it does not play a role in the acute secretory response during nursing. Anatomically, the AL-IZ has an intimate contact with the NIL because the blood passing through the short portal vessels (SPV) bathes it first. Based on this fact it would be hypothesized that locally released and/or produced compounds, like OXY and a-MSH, can be delivered to the AL-IZ. In conjunction, OXY and a-MSH have already been implicated to play a role in the regulation of PRL release during suckling. Therefore, the purpose of this study was to examine the possible local transportation of these hormones into the median eminence and various regions of the pituitary gland of lactating rats. We have measured the concentrations of OXY and α-MSH from tissue samples of nonsuckled (NS) and 10 or 30 min after suckling (S) was initiated using specific RIAs. It has been shown that there are no changes in the concentration of OXY and α-MSH in the AL-IZ and AL-OZ due to suckling stimulus. In contrast, our data provide compelling evidence that OXY is transported into the IL, which can be further increased by suckling stimulus. These data suggest that blood transfusing NL passes through the IL before it is drained into the cavernous sinus, which opens the road for OXY into the general circulation. In addition, our data have unequivocally shown a lack of local delivery of either α MSH or OXY into the AL that raises serious doubt about their possible role in PRL secretion during suckling stimulus.",
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AU - Meszaros, L.

AU - Bodnar, L.

AU - Ahmed, K. W.

AU - Tóth, R.

AU - Julesz, J.

AU - Nagy, G. M.

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