Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

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115 Citations (Scopus)

Abstract

Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions. 1 1"This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi".

Original languageEnglish
JournalBBA - Bioenergetics
DOIs
Publication statusAccepted/In press - Jan 18 2016

Keywords

  • Cancer
  • HIF1-alpha
  • Substrate-level phosphorylation
  • Succinate dehydrogenase
  • Succinate receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology

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