Életet veszélyezteto, terápiarefrakter Clostridium difficile fertozés okozta pseudomembranosus colitis sikeres kezelése széklettranszplantációval.

Translated title of the contribution: [Successful treatment of life-threatening, treatment resistant Clostridium difficile infection associated pseudomembranous colitis with faecal transplantation].

Gergely György Nagy, Csaba Várvölgyi, G. Paragh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Due to world-wide spread of hypervirulent and antibiotic resistant Clostridium difficile strains, the incidence of these infections are dramatically increasing in Hungary with appalling mortality and recurrence rates. Authors present a case of a 59-year-old patient who developed a severe, relapsing pseudomembranous colitis after antibiotic treatment. Life-threatening symptoms of fulminant colitis were successfully treated with prolonged administration of metronidazole and vancomycin, careful supportive therapy and weeks of intensive care. However, a well-documented, severe relapse developed within a week and this time faecal bacteriotherapy was performed. This treatment resulted in a complete cure without any further antibiotic treatment. In relation to this life-saving faecal transplantation, methodology and indications are briefly discussed. In addition, microbiological issues, epidemiological data and threats associated with antibiotic treatment of Clostridium difficile infections are also covered. Finally, relevant professional societies are urged to prepare a national protocol for faecal transplantation, which could allow introduction of this valuable, cost-effective procedure into the routine clinical practice.

Original languageHungarian
Pages (from-to)2077-2083
Number of pages7
JournalOrvosi Hetilap
Volume153
Issue number52
Publication statusPublished - Dec 30 2012

Fingerprint

Pseudomembranous Enterocolitis
Clostridium Infections
Clostridium difficile
Anti-Bacterial Agents
Therapeutics
Recurrence
Hungary
Metronidazole
Colitis
Vancomycin
Critical Care
Fecal Microbiota Transplantation
Costs and Cost Analysis
Mortality
Incidence
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Életet veszélyezteto, terápiarefrakter Clostridium difficile fertozés okozta pseudomembranosus colitis sikeres kezelése széklettranszplantációval. / Nagy, Gergely György; Várvölgyi, Csaba; Paragh, G.

In: Orvosi Hetilap, Vol. 153, No. 52, 30.12.2012, p. 2077-2083.

Research output: Contribution to journalArticle

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