Sikeres autológ haemopoeticus ossejt-transzplantáció gyermekkori, súlyos, terápiarezisztens Crohn-betegségben. Az elso hazai beteg esetének ismertetése

Translated title of the contribution: Successful autologous haemopoietic stem cell transplantation in severe, therapy-resistant childhood-onset Crohn's disease. Report on the first case in Hungary

Gergely Kriván, Dolóresz Szabó, Krisztián Kállay, Gábor Benyó, Csaba Kassa, János Sinkó, Vera Goda, A. Arató, G. Verès

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The biological therapy of Crohn's disease, such as infliximab is a powerful approach in the therapy of inflammatory bowel diseases. However, in some patients with aggressive disease course, even a combined immunosuppressive therapy will not result in permanent remission. Hematopoietic stem cell transplantation has emerged as a new potential therapeutic tool for inflammatory bowel diseases. The authors report the case of a 15-year-old boy with severe Crohn's disease resistant to combined immunosuppressive therapy. After a 3-years course of unsuccessful conventional therapy including infliximab, autologous hematopoietic stem cell transplantation was performed which resulted in a complete remission. One year after transplantation the patient has relapsed, but he could be treated effectively with conventional therapy regiments. To the best of knowledge of the authors, this is the first report in Hungary presenting hematopoietic stem cell therapy in patient with severe Crohn's disease.

Original languageHungarian
Pages (from-to)789-792
Number of pages4
JournalOrvosi Hetilap
Volume155
Issue number20
DOIs
Publication statusPublished - May 1 2014

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Hungary
Stem Cell Transplantation
Crohn Disease
Hematopoietic Stem Cell Transplantation
Immunosuppressive Agents
Inflammatory Bowel Diseases
Therapeutics
Biological Therapy
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
Transplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sikeres autológ haemopoeticus ossejt-transzplantáció gyermekkori, súlyos, terápiarezisztens Crohn-betegségben. Az elso hazai beteg esetének ismertetése. / Kriván, Gergely; Szabó, Dolóresz; Kállay, Krisztián; Benyó, Gábor; Kassa, Csaba; Sinkó, János; Goda, Vera; Arató, A.; Verès, G.

In: Orvosi Hetilap, Vol. 155, No. 20, 01.05.2014, p. 789-792.

Research output: Contribution to journalArticle

Kriván, Gergely ; Szabó, Dolóresz ; Kállay, Krisztián ; Benyó, Gábor ; Kassa, Csaba ; Sinkó, János ; Goda, Vera ; Arató, A. ; Verès, G. / Sikeres autológ haemopoeticus ossejt-transzplantáció gyermekkori, súlyos, terápiarezisztens Crohn-betegségben. Az elso hazai beteg esetének ismertetése. In: Orvosi Hetilap. 2014 ; Vol. 155, No. 20. pp. 789-792.
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