It is shown that whilst the Arg51-Trp52 and Arg60-Tyr61 peptide bonds of β-lipotropin are preferentially split by trypsin-Sepharose in aqueous solution, in a secondary structure promoting environment the Arg60-Tyr61 peptide bond is almost exclusively cleaved. It is suggested that the specificity of intracellular precursor processing may be directed by the conformation of the substrate.
|Number of pages||5|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - Apr 29 1980|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology