Substance P-like immunoreactive neurons in the arcuate nucleus project to the median eminence in rat

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Abstract

Substance P-containing nerve fibers in the median eminence of rat arise in cells located in the arcuate nucleus. Two days following surgical lesioning of the median eminence immunoreactive substance P accumulated in neuronal perikarya in the middle part (rostrocaudally) of the arcuate nucleus, mainly in its ventromedial portion. Substance P-immunostained cells appeared nowhere else in the hypothalamus following surgical lesion of the median eminence while they were found in several hypothalamic and extrahypothalamic cell groups after cochicine treatment.

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalBrain research
Volume486
Issue number2
DOIs
Publication statusPublished - May 8 1989

Keywords

  • Arcuate nucleus
  • Hypothalamic lesion
  • Immunohistochemistry
  • Median eminence
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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