Subchronic mercury treatment of rats in different phases of ontogenesis: Functional effects on the central and peripheral nervous system

A. Papp, L. Nagymajtényi, Tünde Vezér

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Electrophysiological changes caused by inorganic mercury administration during the pre- and/or postnatal development were studied. Pregnant female Wistar rats were treated, by gavage, with 0.4, 0.8 or 1.6 mg/kg mercury (HgCl 2 diluted in distilled water): 1/ from day 5 to 15 during pregnancy (P protocol); 2/ from day 5 to 15 of pregnancy + for 4 weeks of lactation (P+L protocol); 3/ from day 5 to 15 of pregnancy + for 4 weeks of lactation, and the offspring were further treated for 8 weeks post-weaning (P+L+P protocol). Electrophysiological parameters (electrocorticogram, cortical evoked potentials, conduction velocity and refractory periods of peripheral nerve) of the male offspring from dams in the groups treated according to the above protocols were investigated at the age of 12 weeks. The rats' spontaneous and evoked electrophysiological activity underwent dose- and treatment-dependent changes following the treatment (increased frequency of spontaneous activity, lengthened latencies and duration of evoked potentials, lower conduction velocity of the peripheral nerve, etc.). In the same rats, however, the treatment failed to cause major signs of general intoxication. The results emphasize the functional neurotoxic risk arising from the continuous presence of inorganic mercury in the human environment, and point to possible use of early functional changes for monitoring the effects of mercury.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalFood and Chemical Toxicology
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

peripheral nervous system
Peripheral Nervous System
Neurology
Mercury
mercury
central nervous system
ontogeny
Rats
Central Nervous System
evoked potentials
peripheral nerves
rats
Bioelectric potentials
pregnancy
Peripheral Nerves
Evoked Potentials
Lactation
Pregnancy
lactation
dams (hydrology)

Keywords

  • Conduction velocity
  • Electrocorticogram
  • Evoked potential
  • Mercuric chloride
  • Rat
  • Refractory period

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

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abstract = "Electrophysiological changes caused by inorganic mercury administration during the pre- and/or postnatal development were studied. Pregnant female Wistar rats were treated, by gavage, with 0.4, 0.8 or 1.6 mg/kg mercury (HgCl 2 diluted in distilled water): 1/ from day 5 to 15 during pregnancy (P protocol); 2/ from day 5 to 15 of pregnancy + for 4 weeks of lactation (P+L protocol); 3/ from day 5 to 15 of pregnancy + for 4 weeks of lactation, and the offspring were further treated for 8 weeks post-weaning (P+L+P protocol). Electrophysiological parameters (electrocorticogram, cortical evoked potentials, conduction velocity and refractory periods of peripheral nerve) of the male offspring from dams in the groups treated according to the above protocols were investigated at the age of 12 weeks. The rats' spontaneous and evoked electrophysiological activity underwent dose- and treatment-dependent changes following the treatment (increased frequency of spontaneous activity, lengthened latencies and duration of evoked potentials, lower conduction velocity of the peripheral nerve, etc.). In the same rats, however, the treatment failed to cause major signs of general intoxication. The results emphasize the functional neurotoxic risk arising from the continuous presence of inorganic mercury in the human environment, and point to possible use of early functional changes for monitoring the effects of mercury.",
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AU - Papp, A.

AU - Nagymajtényi, L.

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N2 - Electrophysiological changes caused by inorganic mercury administration during the pre- and/or postnatal development were studied. Pregnant female Wistar rats were treated, by gavage, with 0.4, 0.8 or 1.6 mg/kg mercury (HgCl 2 diluted in distilled water): 1/ from day 5 to 15 during pregnancy (P protocol); 2/ from day 5 to 15 of pregnancy + for 4 weeks of lactation (P+L protocol); 3/ from day 5 to 15 of pregnancy + for 4 weeks of lactation, and the offspring were further treated for 8 weeks post-weaning (P+L+P protocol). Electrophysiological parameters (electrocorticogram, cortical evoked potentials, conduction velocity and refractory periods of peripheral nerve) of the male offspring from dams in the groups treated according to the above protocols were investigated at the age of 12 weeks. The rats' spontaneous and evoked electrophysiological activity underwent dose- and treatment-dependent changes following the treatment (increased frequency of spontaneous activity, lengthened latencies and duration of evoked potentials, lower conduction velocity of the peripheral nerve, etc.). In the same rats, however, the treatment failed to cause major signs of general intoxication. The results emphasize the functional neurotoxic risk arising from the continuous presence of inorganic mercury in the human environment, and point to possible use of early functional changes for monitoring the effects of mercury.

AB - Electrophysiological changes caused by inorganic mercury administration during the pre- and/or postnatal development were studied. Pregnant female Wistar rats were treated, by gavage, with 0.4, 0.8 or 1.6 mg/kg mercury (HgCl 2 diluted in distilled water): 1/ from day 5 to 15 during pregnancy (P protocol); 2/ from day 5 to 15 of pregnancy + for 4 weeks of lactation (P+L protocol); 3/ from day 5 to 15 of pregnancy + for 4 weeks of lactation, and the offspring were further treated for 8 weeks post-weaning (P+L+P protocol). Electrophysiological parameters (electrocorticogram, cortical evoked potentials, conduction velocity and refractory periods of peripheral nerve) of the male offspring from dams in the groups treated according to the above protocols were investigated at the age of 12 weeks. The rats' spontaneous and evoked electrophysiological activity underwent dose- and treatment-dependent changes following the treatment (increased frequency of spontaneous activity, lengthened latencies and duration of evoked potentials, lower conduction velocity of the peripheral nerve, etc.). In the same rats, however, the treatment failed to cause major signs of general intoxication. The results emphasize the functional neurotoxic risk arising from the continuous presence of inorganic mercury in the human environment, and point to possible use of early functional changes for monitoring the effects of mercury.

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